TRAILR2/TNFRSF10B Products

Description

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-2). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Bioinformatics

Entrez	21933 Mouse 8795 Human
Uniprot	AAH01281 Human AAH01281.1 Human AF012535 Human NM_003842 Human NP_003833 Human NP_671716 Human O14763 Human Q9QZM4 Mouse
Product By Gene ID	8795
Alternate Names	CD262 antigen CD262 death domain containing receptor for TRAIL/Apo-2L Death receptor 5 DR5TRICK2B Fas-like protein KILLER/DR5 KILLERapoptosis inducing protein TRICK2A/2B TNF-related apoptosis-inducing ligand receptor 2 TRAIL receptor 2 TRAIL-R2apoptosis inducing receptor TRAIL-R2 TRAILR2cytotoxic TRAIL receptor-2 TRICK2 TRICK2A TRICKB tumor necrosis factor receptor superfamily member 10B tumor necrosis factor receptor superfamily, member 10b tumor necrosis factor receptor-like protein ZTNFR9 ZTNFR9

Research Areas for TRAILR2/TNFRSF10B

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer