TRAILR2/TNFRSF10B Antibody (JA03-38)

Western Blot: TRAILR2/TNFRSF10B Antibody (JA03-38) [NBP2-67225] - Analysis of DR5 on HL-60 cell using anti-DR5 antibody at 1/1,000 dilution.

Immunohistochemistry-Paraffin: TRAILR2/TNFRSF10B Antibody (JA03-38) [NBP2-67225] - Analysis of paraffin-embedded human tonsil tissue using anti-DR5 antibody. Counter stained with hematoxylin.

Flow Cytometry: TRAILR2/TNFRSF10B Antibody (JA03-38) [NBP2-67225] - Flow cytometric analysis of SW480 cells with TRAILR2/TNFRSF10B antibody at 1/100 dilution (red) compared with an unlabeled control (cells without incubation with primary antibody; black).

Immunohistochemistry-Paraffin: TRAILR2/TNFRSF10B Antibody (JA03-38) [NBP2-67225] - Analysis of paraffin-embedded human colon cancer tissue using anti-DR5 antibody. Counter stained with hematoxylin.

Immunohistochemistry-Paraffin: TRAILR2/TNFRSF10B Antibody (JA03-38) [NBP2-67225] - Analysis of paraffin-embedded human liver tissue using anti-DR5 antibody. Counter stained with hematoxylin.

Immunohistochemistry-Paraffin: TRAILR2/TNFRSF10B Antibody (JA03-38) [NBP2-67225] - Analysis of paraffin-embedded human placenta tissue using anti-DR5 antibody. Counter stained with hematoxylin.

Product Discontinued

TRAILR2/TNFRSF10B Antibody (JA03-38) Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Synthetic peptide within Human TRAILR2/TNFRSF10B aa 391-440 / 440. (SwissProt: O14763 Human)
• Localization: Membrane.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: TNFRSF10B
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:50-1:100
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Immunoprecipitation
  • Western Blot 1:500-1:1000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: TBS (pH7.4), 0.05% BSA, 40% Glycerol
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for TRAILR2/TNFRSF10B Antibody (JA03-38)

• CD262 antigen
• CD262
• death domain containing receptor for TRAIL/Apo-2L
• Death receptor 5
• DR5
• DR5TRICK2B
• Fas-like protein
• KILLER/DR5
• KILLERapoptosis inducing protein TRICK2A/2B
• TNF-related apoptosis-inducing ligand receptor 2
• TNFRSF10B
• TRAIL R2
• TRAIL receptor 2
• TRAILR2
• TRAIL-R2apoptosis inducing receptor TRAIL-R2
• TRAILR2cytotoxic TRAIL receptor-2
• TRICK2
• TRICK2A
• TRICKB
• tumor necrosis factor receptor superfamily member 10B
• tumor necrosis factor receptor superfamily, member 10b
• tumor necrosis factor receptor-like protein ZTNFR9
• ZTNFR9

Background

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-2). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNFRSF10B