TRA-1-60® Antibody (TRA-1-60) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: TRA-1-60
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

TRA-1-60® Antibody (TRA-1-60) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human TRA‑1‑60(R).
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TRA-1-60(R) Antibody (TRA-1-60) [Alexa Fluor™ Plus 488]

• GCTM-2 antigen
• GP135
• gp200
• PC
• PCLP
• PCLP-1
• PDX
• Podocalyxin
• Podocalyxin-like protein 1
• PODXL1
• TRA160(R)
• TRA-1-60(R)

Background

TRA-1-60 is a monoclonal antibody raised against a cell surface antigen of human embryonal carcinoma (EC) cells (1). The TRA-1-60 epitope is also found on human embryonic stem (ES) cells and primordial germ cells, and TRA-1-60 serves as a serum marker in patients with germ cell tumors (2‑4). Investigation into the identity of the TRA-1-60 epitope demonstrated that it is a carbohydrate carried by a cell surface, sialylated, keratan sulfate proteoglycan (5). Subsequent evidence implicated podocalyxin as a carrier for the TRA-1-60 epitope (6).

1. Andrews, P. et al. (1984) Hybridoma 3:347.
2. Thomson, J. et al. (1998) Science 282:1145.
3. Giwercman, A. et al. (1993) Cancer 72:1308.
4. Marrink, J. et al. (1991) Int. J. Cancer 49:368.
5. Badcock, G. et al. (1999) Cancer Res. 59:4715.
6. Schopperle, W. and W. DeWolf (2007) Stem Cells 25:723.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.