TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386)

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Western Blot: TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386) [NB100-61088] - Analysis of Thyroid Hormone, b-isotype in brain lysate using this antibody at 1:1000. Showing specific immunolabeling of the ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
2386
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386) Summary

Immunogen
Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, beta-isotype.
Specificity
Specific for the ~55k TR-beta protein.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
THRB
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Protein G purified

Alternate Names for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386)

  • avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2
  • c-erbA-2
  • c-erbA-beta
  • ERBA2MGC126109
  • ERBA-BETA
  • GRTH
  • MGC126110
  • NR1A2
  • NR1A2thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a)oncogene homolog 2)
  • Nuclear receptor subfamily 1 group A member 2
  • oncogene ERBA2
  • PRTH
  • THR1pituitary resistance to thyroid hormone
  • THRB
  • THRB1
  • THRB2
  • thyroid hormone receptor beta 1
  • thyroid hormone receptor beta
  • thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a)oncogene homolog 2, avian)
  • TR beta 1
  • v-ErbA2

Background

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol THRB
Entrez
Uniprot