TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386) - Azide Free

Western Blot: TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386) [NB100-61088] - Analysis of Thyroid Hormone, b-isotype in brain lysate using this antibody at 1:1000. Showing specific immunolabeling of the 58k TR-a protein.

• Reactivity: Hu
• Applications: WB
• Clone: 2386
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide Free

TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386) - Azide Free Summary

• Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH. Accession # P10828
• Specificity: Specific for endogenous levels of the ~55 kDa TR beta 1/NR1A2/Thyroid Hormone Receptor beta protein.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: THRB
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000
• Theoretical MW: 55 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
• Preservative: No Preservative
• Purity: Protein G purified

Alternate Names for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386) - Azide Free

• avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2
• c-erbA-2
• c-erbA-beta
• ERBA2MGC126109
• ERBA-BETA
• GRTH
• MGC126110
• NR1A2
• NR1A2thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a)oncogene homolog 2)
• Nuclear receptor subfamily 1 group A member 2
• oncogene ERBA2
• PRTH
• THR1pituitary resistance to thyroid hormone
• THRB
• THRB1
• THRB2
• thyroid hormone receptor beta 1
• thyroid hormone receptor beta
• thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a)oncogene homolog 2, avian)
• TR beta 1
• v-ErbA2

Background

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: THRB
• Entrez:
  • 7068(Human)
• Uniprot:
  • P10828(Human)