TORC2 Antibody

Product Discontinued

TORC2 Antibody Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residues 475 and 500 of human Transducer of Regulated cAMP Responsive Element-Binding Protein (CREB) 2 using the numbering given in entry NP_859066.1 (GeneID 200186).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CRTC2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunoprecipitation 1-4 ug/mg of lysate
  • Western Blot 1:2000-1:10000
• Application Notes: Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID 24755741)
• Theoretical MW: 73 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control:

  TORC2 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: TBS and 0.1% BSA
• Preservative: 0.09% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for TORC2 Antibody

• CREB regulated transcription coactivator 2
• CREB-regulated transcription coactivator 2
• CRTC2
• TORC2
• TORC-2
• TORC2transducer of regulated cAMP response element-binding protein (CREB) 2
• Transducer of CREB protein 2
• Transducer of regulated cAMP response element-binding protein 2

Background

TORC2 (transducer of regulated CREB activity 2) is part of a family of CREB (cAMP response element-binding protein) coactivators that also includes TORC1 and TORC3. These proteins function to activate CREB-dependent transcription in response to cAMP and calcium signaling pathways. TORC2 has been found to be pivotal to the process of gluconeogenesis. TORC2 is also known as CREB regulated transcription activator 2, and CRTC2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TORC2 Antibody (NB100-79816)(2)

Publications using NB100-79816

• Cicerchi Christina, Li Nanxing, Kratzer James et al. Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids. FASEB J. 2014-04-22 [PMID: 24755741] (ICC/IF, WB, Human)
• Jeanneteau FD, Lambert WM, Ismaili N et al. BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A 2012-01-01 [PMID: 22232675]

Bioinformatics

• Gene Symbol: CRTC2
• Entrez:
  • 200186(Human)
• Uniprot:
  • Q53ET0(Human)