TORC1 Antibody (505531) [Alexa Fluor® 532]

• Reactivity: Mu
• Applications: IHC
• Clone: 505531
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 532

TORC1 Antibody (505531) [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant mouse TORC1
  Gln384-Gln471
  Accession # Q68ED7
• Specificity: Detects mouse TORC1 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TORC1 Antibody (505531) [Alexa Fluor® 532]

• CREB regulated transcription coactivator 1
• CRTC1
• FLJ14027WAMTP1
• KIAA0616Transducer of regulated cAMP response element-binding protein 1
• MECT1
• MECT1CREB-regulated transcription coactivator 1
• mucoepidermoid carcinoma translocated 1
• Mucoepidermoid carcinoma translocated protein 1
• TORC1
• TORC1TORC-1
• Transducer of CREB protein 1
• transducer of regulated cAMP response element-binding protein (CREB) 1
• WAMTP1

Background

TORC1, also known as CREB-regulated transcription coactivator 1 (crtc1), is a 67 kDa member of the TORC family. Mouse TORC1 is 630 amino acids (aa) in length. It contains multiple potential sites for phosphorylation and a serine-rich region from aa 295‑365. Mouse TORC1 is 97% and 90% aa identical to rat and human TORC1, respectively. TORC1 is highly expressed in specific regions of the brain including the cortex, hippocampus, and striatum. It functions as a transcription coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.