Tmp21/p23 Antibody [PE]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ch, Pm, RbSpecies Glossary
Applications WB, IHC, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
PE

Order Details

Tmp21/p23 Antibody [PE] Summary

Immunogen
A synthetic peptide made to an internal sequence of the human TMP21/TMED10 protein (within residues 100-200). [Swiss-Prot# P49755]
Localization
Type I membrane. Golgi cisternae.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TMED10
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockdown Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Tmp21/p23 Antibody [PE]

  • 21 kDa transmembrane-trafficking protein
  • p23
  • P24(DELTA)
  • p24delta
  • S31I125
  • S31III125
  • TMED10
  • Tmp21
  • TMP21Tmp-21-I
  • transmembrane emp24 domain-containing protein 10
  • transmembrane emp24-like trafficking protein 10 (yeast)
  • Transmembrane protein Tmp21,21 kDa transmembrane trafficking protein

Background

TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase, but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites, and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21, indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity and Abeta production, but not epsilon-secretase activity, demonstrating that TMP21 can modulate gamma-secretase activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TMED10