TMEFF2/Tomoregulin-2 Antibody [Janelia Fluor® 549]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Janelia Fluor 549

TMEFF2/Tomoregulin-2 Antibody [Janelia Fluor® 549] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human TMEFF2/Tomoregulin‑2
  Arg34-Val320
  Accession # Q9UIK5
• Specificity: Detects human TMEFF2/Tomoregulin‑2 in direct ELISAs and Western blots. In direct ELISAs, approximately 15% cross-reactivity with recombinant human TMEFF1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: TMEFF2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for TMEFF2/Tomoregulin-2 Antibody [Janelia Fluor® 549]

• CT120.2
• HPP1member 2
• Hyperplastic polyposis protein 1
• TENB2
• TMEFF2
• Tomoregulin2
• Tomoregulin-2
• TPEFtomoregulin
• TR-2
• transmembrane protein TENB2
• transmembrane protein with EGF-like and two follistatin-like domains 2
• Transmembrane protein with EGF-like and two follistatin-like domains
• TRtomoregulin-2

Background

TMEFF2(transmembrane protein with EGF-like and two follistatin-like domains 2), a gene encoding a plasma membrane protein with two follistatin-like domains and one epidermal growth factor-like domain, had limited normal tissue distribution and was highly overexpressed in prostate cancer. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. Clone J4B6, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TMEFF2 protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TMEFF2