TMEFF2/Tomoregulin-2 Products

Description

TMEFF2 (transmembrane protein with an EGF-like and two Follistatin-like domains 2), also known as Tomoregulin-2, is a type I transmembrane glycoprotein that contains two extracellular follistatin modules, an extracellular EGF-like domain, a transmembrane domain, and a short conserved cytoplasmic tail (1) Soluble extracellular domains of both TMEFF1 and 2 can be generated by proteolytic cleavage. TMEFF2 amino acid (aa) sequences are 98.9% identical for human and mouse orthologs (1). The differential methylation of TMEFF2 can be related to the response to therapy and survival outcomes of the stages of cancers such as breast, prostate, lung, bladder, colon and rectal, gallbladder, renal, oesophageal, cardiac, stomach/gastric, ovarian, multiple myeloma, glioblastoma, and mesothelioma. The range of tissue expression of TMEFF2 functions as a possible biomarker and/or therapeutic target (1). Studies showed that TMEFF2 binds and inhibits PDGF-AA (2, 3). It also inhibits the proliferation of DU145 and PC3 prostate cancer cell lines (4). The amyloid-b protein, its precursor AbPP, and amyloid- b proteins AbPOs also bind TMEFF2, suggesting a neuroprotective role on Alzheimer's disease (5). TMEFF2's diverse function includes metabolism, embryonic development, cytoskeletal binding, extracellular matrix binding, chromatin binding and interaction of RNA polymerase II with DNA (6), and neuronal development (7).

Bioinformatics

Uniprot	Q9UIK5.1
Product By Gene ID	23671
Alternate Names	CT120.2 HPP1member 2 Hyperplastic polyposis protein 1 TENB2 TMEFF2 Tomoregulin2 Tomoregulin-2 TPEFtomoregulin TR-2 transmembrane protein TENB2 transmembrane protein with EGF-like and two follistatin-like domains 2 Transmembrane protein with EGF-like and two follistatin-like domains TRtomoregulin-2