TMEFF1/Tomoregulin-1 Antibody (249511)

• Reactivity: Hu
• Applications: WB
• Clone: 249511
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

TMEFF1/Tomoregulin-1 Antibody (249511) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human TMEFF1/Tomoregulin‑1
  Ser40-Thr328
  Accession # Q8IYR6
• Specificity: Detects human TMEFF1/Tomoregulin‑1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse TMEFF1 or recombinant human TMEFF2 is observed.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: TMEFF1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TMEFF1/Tomoregulin-1 Antibody (249511)

• C9orf2
• H7365member 1
• TMEFF1
• Tomoregulin1
• Tomoregulin-1
• TR-1
• Transmembrane protein with EGF-like and one follistatin-like domain
• transmembrane protein with EGF-like and two follistatin-like domains 1

Background

TMEFF1 (Transmembrane protein with EGF-like and two Follistatin-like domains 1), also known as tomoregulin 1 is a type I transmembrane glycoprotein that contains two follistatin modules and an EGF domain in its extracellular domain, a transmembrane domain and a short cytoplasmic tail. The extracellular domain can be released as a soluble protein. TMEFF1 selectively regulates nodal but not activin signaling through direct binding to the nodal co-receptor, Cripto.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TMEFF1/Tomoregulin-1 Antibody (MAB1919)(2)

Publications using MAB1919

• Menz C, Parsi M, Adams J, Sideek M, Kopecki Z, Cowin A, Gibson M LTBP-2 Has a Single High-Affinity Binding Site for FGF-2 and Blocks FGF-2-Induced Cell Proliferation. PLoS ONE, 2015-08-11;10(8):e0135577. 8/11/2015 [PMID: 26263555]
• Condomines M, Hose D, Reme T, Requirand G, Hundemer M, Schoenhals M, Goldschmidt H, Klein B Gene expression profiling and real-time PCR analyses identify novel potential cancer-testis antigens in multiple myeloma. J. Immunol., 2009-06-19;183(2):832-40. 2009-06-19 [PMID: 19542363] (Western Blot, Human)

Bioinformatics

• Gene Symbol: TMEFF1
• Uniprot:
  • Q8IYR6()