TMC6 Antibody

Images

 
Western Blot: TMC6 Antibody [NBP1-76891] - A-20 cell lysate with TMC6 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry-Paraffin: TMC6 Antibody [NBP1-76891] - Human spleen with TMC6 antibody at 2.5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

TMC6 Antibody Summary

Immunogen
Antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human EVER1. The immunogen is located within the first 50 amino acids of EVER1.
Specificity
At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TMC6
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Control Peptide
TMC6 Peptide (NBP1-76891PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TMC6 Antibody

  • epidermodysplasia verruciformis 1
  • Epidermodysplasia verruciformis protein 1
  • EVER1FLJ17776
  • EVIN1EV1
  • expressed in activated T/LAK lymphocytes
  • LAK-4P
  • Protein LAK-4
  • transmembrane channel-like 6
  • transmembrane channel-like protein 6

Background

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance. At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TMC6
Uniprot