TIA1 Antibody (TRIA1-1)

Western Blot: TIA1 Antibody (TRIA1-1) [NBP3-27932] - Western blot testing of A) HepG2, B) PC3 and C) HeLa cell lysate wiht TIA1 antibody (clone TRIA1-1). The long and short forms differ by 17 amino acids. Predicted molecular weight: ~43kDa and ~15kDa (granulocyte-associated isoform).

• Reactivity: Hu
• Applications: WB, Flow, ICC/IF
• Clone: TRIA1-1
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: 0.2 mg/ml

TIA1 Antibody (TRIA1-1) Summary

• Description: Novus Biologicals Mouse TIA1 Antibody (TRIA1-1) (NBP3-27932) is a monoclonal antibody validated for use in WB, Flow and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Human partial recombinant protein (amino acids 279-380) was used as the immunogen for this TIA1 antibody.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: TIA1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot 1 - 2 ug/mL

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: PBS, 0.1 mg/ml BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Protein G purified

Alternate Names for TIA1 Antibody (TRIA1-1)

• cytotoxic granule-associated RNA-binding protein
• nucleolysin TIA-1 isoform p40
• p40-TIA-1 (containing p15-TIA-1)
• p40-TIA-1
• RNA-binding protein TIA-1
• T-cell-restricted intracellular antigen-1
• TIA1 cytotoxic granule-associated RNA binding protein
• TIA1 cytotoxic granule-associated RNA-binding protein
• TIA-1

Background

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TIA1
• Uniprot:
  • P31483(Human)