TIA1 Products

Description

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.

Bioinformatics

Entrez	7072 Human 21841 Mouse 312510 Rat
Uniprot	NP_071320.1 Human
Product By Gene ID	7072
Alternate Names	cytotoxic granule-associated RNA-binding protein nucleolysin TIA-1 isoform p40 p40-TIA-1 (containing p15-TIA-1) p40-TIA-1 RNA-binding protein TIA-1 T-cell-restricted intracellular antigen-1 TIA1 cytotoxic granule-associated RNA binding protein TIA1 cytotoxic granule-associated RNA-binding protein TIA-1

Research Areas for TIA1

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Apoptosis
Immunology