Thymosin beta 10 Antibody [Unconjugated]

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Western blot shows lysates of HEK293 human embryonic kidney cell line, NTera‑2 human testicular embryonic carcinoma cell line, C6 rat glioma cell line, and Balb/3T3 mouse embryonic fibroblast cell line. PVDF ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price

Thymosin beta 10 Antibody [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human Thymosin beta 10
Ala2-Ser44
Accession # P63313
Specificity
Detects human Thymosin beta 10 in direct ELISAs. Detects human, mouse, and rat Thymosin beta 10 in Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) Thymosin beta 4 and rhThymosin beta 16 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
TMSB10
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Sterile PBS to a final concentration of 0.2 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Thymosin beta 10 Antibody [Unconjugated]

  • MIG12
  • migration-inducing gene 12
  • migration-inducing protein 12
  • PTMB10
  • TB10
  • THYB10
  • Thymosin beta 10
  • thymosin beta-10
  • TMSB10

Background

Thymosin beta 10 (T beta 10) is a 6.5 kDa member of the beta -thymosin family of molecules. Members of this family range from 41-44 amino acids (aa) in length, and possess an isoelectric point that lies between pH 5.0-7.0. Multiple cell types produce T beta 10, either constitutively, or after stimulation. They include monocytes/macrophages, endothelial cells, thyroid epithelium, spermatids, fetal cerebellar Purkinje cells plus renal tubule epithelium, and multiple tumor types. T beta 10 is principally an intracellular molecule. It forms a 1:1 complex with G-actin and blocks F-actin polymerization. This regulates the availablility of actin monomers for filament formation and subsequent cell migration.  It is also known to be noncanonically secreted, acting on endothelium and blocking angiogenesis. Mature human T beta 10 is 43 aa in length (aa 2-44) (SwissProt #:P63313). It contains an actin-binding site (aa 18-23), an N-terminal acetylated alanine, four acetylated lysines (#4; 15; 26; 39), and one phosphorylation site at Thr23. Mature T beta 10 is identical to mouse T beta 10 in aa sequence, and it shares 74% aa sequence identity with its human family member T beta 4.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TMSB10
Uniprot