THSD1 Antibody [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 647

THSD1 Antibody [Alexa Fluor® 647] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human THSD1 Isoform 2
  Glu25-Ile361
  Accession # Q9NS62
• Specificity: Detects human THSD1 Isoform 2 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross‑reactivity with recombinant mouse THSD1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for THSD1 Antibody [Alexa Fluor® 647]

• thrombospondin type-1 domain-containing protein 1
• thrombospondin, type I, domain 1
• thrombospondin, type I, domain containing 1,4833423O18Rik
• THSD1
• TMTSP
• TMTSPMGC74971
• Transmembrane molecule with thrombospondin module
• UNQ3010

Background

THSD1 (thrombospondin type 1 domain‑containing protein 1; also TMTSP) is a 90‑100 kDa type I transmembrane protein that is reminiscent of Unc5h proteins. It is expressed on embryonic endothelial and hematopoietic stem cells and may be involved in cell‑cell interactions. Mature human THSD1 is 827 amino acids (aa) in length. It contains a 388 aa extracellular domain (ECD) (aa 25‑412) and a 418 aa cytoplasmic region (aa 434‑851). The ECD possesses three Ig‑like domains
(aa 156‑316) and one TSP type‑1 domain (aa 340‑393). There is one potential alternate start site at Met380 and two splice variants, one of which shows a deletion of aa 341‑393 and a second that shows a 36 aa substitution for aa 394‑851, generating a soluble form. Over aa 25‑361, human THSD1 is 76% aa identical to mouse THSD1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.