Thrombospondin-1 Native Protein

Product Discontinued

Thrombospondin-1 Native Protein Summary

• Description: Native Thrombospondin-1
  
  

  Source:Human platelets
  Amino Acid Sequence:(P07996)

• Source: Human Platelets
• Protein/Peptide Type: Native Protein
• Gene: THBS1
• Purity: >95%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • SDS-Page
• Theoretical MW: 420 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20 to -80C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from 20 mM Tris-HCl (pH 8.0), 600 mM NaCl, 2 mM CaCl2, 20% sucrose
• Concentration: Lyoph
• Purity: >95%, by SDS-PAGE
• Reconstitution Instructions: Reconstitute with deionized H2O.

Alternate Names for Thrombospondin-1 Native Protein

• THBS
• THBS1
• THBS-1
• thrombospondin 1
• Thrombospondin1
• Thrombospondin-1
• thrombospondin-1p180
• TSP-1
• TSP1thrombospondin-1
• TSPTSP-1

Background

Thrombospondin (TSP) is a cellular adhesion protein isolated from human platelets that had been stimulated with thrombin . TSP is a component of the coagulation mechanism and is believed to have potential as a marker for platelet activation and renal failure. Found in multiple biological processes including angiogenesis, apoptosis, activation of TGF-Beta and immune regulation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Publications for Thrombospondin-1 Native Protein (NBP1-99789)(2)

Publications using NBP1-99789

• Yao M, Ganguly S, Shin JHS, Elbayoumi T Efficient Ex Vivo Screening of Agents Targeting Thrombospondin1-Induced Vascular Dysfunction Using a Digital Multiwire Myograph System Methods and protocols 2021-10-14 [PMID: 34698263]
• Yao M, Sturdivant J, Ebrahimi A et al. Novel Pharmaceutical Strategy for Selective Abrogation of TSP1-Induced Vascular Dysfunction by Decoy Recombinant CD47 Soluble Receptor in Prophylaxis and Treatment Models Biomedicines 2021-07-02 [PMID: 34205047]

Bioinformatics

• Gene Symbol: THBS1