Tenascin C Antibody (EPR4219)

Product Discontinued

Tenascin C Antibody (EPR4219) Summary

• Immunogen: A synthetic peptide corresponding to residues in human Tenascin-C was used as an immunogen.
• Clonality: Monoclonal
• Host: Rabbit
• Gene: TNC
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:10-1:1000
  • Immunocytochemistry/ Immunofluorescence 1:100-250
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:100-250
  • Western Blot 1:1000-10000
• Theoretical MW: 260 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 49% PBS, 0.05% BSA and 50% Glycerol
• Preservative: 0.01% Sodium Azide
• Purity: Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for Tenascin C Antibody (EPR4219)

• 150-225
• Cytotactin
• Glioma-associated-extracellular matrix antigen
• GMEM
• GP 150-225
• hexabrachion (tenascin C, cytotactin)
• hexabrachion (tenascin)
• Hexabrachion
• HXB
• HXBcytotactin
• JI
• MGC167029
• Myotendinous antigen
• neuronectin
• Tenascin C
• Tenascin J1
• tenascin
• tenascin-C isoform 14/AD1/16
• Tenascin-C
• TNC
• TN-C
• TNGP

Background

Tenascin-C is the founding member of a family of extracellular matrix glycoproteins that includes tenascin-X, -R and -W. Tenascin-C interacts with several other extracellular matrix molecules and cell-surface receptors, thus affecting tissue architecture, tissue resilience and cell responses (1). It also modulates cell migration; proliferation; and cellular signaling through induction of pro-inflammatory cytokines and oncogenic signaling molecules, amongst other mechanisms (1). Tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer (1). In the adult, Tenascin-C remains present in tendons and myotendinous junctions in the perichondrium and periosteum, as well as in smooth muscle (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for Tenascin C Antibody (NBP1-96583). (Showing 1 - 1 of 1 FAQ).

1. One of our clients is looking for antibodies against tenascin C and fibronectin that could be used for FFPE rat tissues. These antibodies should exclusively recognize tenascin C and fibronectin and do not cross react with each other. Can you inform me if you have these antibodies?
   • Here is a link to Tenascin C antibodies we have validated in rat tissues for IHC-P Here are antibodies we have validated in fibronectin in rat tissues for IHC-P

Bioinformatics

• Gene Symbol: TNC
• Entrez:
  • 3371(Human)
• Uniprot:
  • P24821(Human)