TCIRG1 Antibody (6H3)

Western Blot: TCIRG1 Antibody (6H3) [H00010312-M01] - Detection against Immunogen (36.74 KDa) .

• Reactivity: Hu, Mu
• Applications: WB, ELISA, IHC, IHC-Fr
• Clone: 6H3
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

TCIRG1 Antibody (6H3) Summary

• Immunogen: TCIRG1 (AAH18133, 121 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. QLHQLQLHAAVLRQGHEPQLAAAHTDGASERTPLLQAPGGPHQDLRVNFVAGAVEPHKAPALERLLWRACRGFLIASFRELEQPLEHPVTGEPATWMTFL
• Specificity: TCIRG1 - T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (6H3)
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: TCIRG1
• Purity: Ascites

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Western Blot 1:500
• Application Notes: Antibody Reactive against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: Ascites

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for TCIRG1 Antibody (6H3)

• a3
• Atp6i
• ATP6N1C
• ATP6N1Cspecific 116-kDa vacuolar proton pump subunit
• ATP6V0A3T-cell immune response cDNA 7
• OC-116 kDa
• OC116
• OC-116
• OC-116kDa
• OC116Vph1
• OPTB1
• Osteoclastic proton pump 116 kDa subunit
• Stv1
• T-cell immune regulator 1
• T-cell immune response cDNA7 protein
• T-cell, immune regulator 1
• T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a
• T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
• T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein aisoform 3
• T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
• TCIRG1
• TIRC7
• TIRC7ATPase, H+ transporting, 116kD
• Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
• vacuolar proton translocating ATPase 116 kDa subunit A
• V-ATPase 116 kDa isoform a3
• V-ATPase 116-kDa
• Vph1
• V-type proton ATPase 116 kDa subunit a isoform 3
• V-type proton ATPase 116 kDa subunit a

Background

Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TCIRG1 Antibody (H00010312-M01)(3)

Publications using H00010312-M01

• Henriksen K, Andreassen KV, Thudium CS et al. A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts. Bone. 2012 Jun 19 [PMID: 22722081]
• Schinke T, Schilling AF, Baranowsky A et al. Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat Med. 2009 Jun 01 [PMID: 19448635]
• Schulz N, Dave MH, Stehberger PA et al. Differential Localization of Vacuolar H+-ATPases Containing a1, a2, a3, or a4 (ATP6V0A1-4) Subunit Isoforms Along the Nephron. Cell Physiol Biochem;20(1-4):109-20. 2007 [PMID: 17595521]

Bioinformatics

• Gene Symbol: TCIRG1
• OMIM:
  • 259700(Human)