TBC1D1 Antibody

Images

 
Western Blot: TBC1D1 Antibody [H00023216-B02P] - Analysis of TBC1D1 expression in transfected 293T cell line by TBC1D1 polyclonal antibody. Lane 1: TBC1D1 transfected lysate(128.48 KDa). Lane 2: Non-transfected lysate.
Immunocytochemistry/ Immunofluorescence: TBC1D1 Antibody [H00023216-B02P] - Analysis of purified antibody to TBC1D1 on HeLa cell. (antibody concentration 10 ug/ml)

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

TBC1D1 Antibody Summary

Immunogen
TBC1D1 (AAH50321.3, 1 a.a. ~ 1168 a.a) full-length human protein.
Isotype
IgG
Clonality
Polyclonal
Host
Mouse
Gene
TBC1D1
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunocytochemistry/Immunofluorescence
Application Notes
This antibody is useful for Western Blot

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for TBC1D1 Antibody

  • KIAA1108TBC
  • TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
  • TBC1 domain family member 1
  • TBC1

Background

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TBC1D1
Uniprot