Tau Antibody (tau-C3)

Product Discontinued

Tau Antibody (tau-C3) Summary

• Immunogen: Peptide corresponding to the C-terminus of tau truncated as aspartic acid 421.
• Marker: pan-Neuronal Marker
• Specificity: Reacts with Tau, caspase cleaved (truncated at Asp421). The antibody shows no reactivity with full length tau nor other tau C-terminal truncations. The antibody stains amyloid beta treated neurons and brain tissue in Alzheimer's disease, more specifically it stains a subset of neurofibrillary tangles, tau-containing neuritic plaques and neuropil threads.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: MAPT
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000
• Theoretical MW: 43 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Concentration: 1 mg/ml
• Purity: Protein A or G purified

Notes

Relevant Entrez Gene Numbers: NM_005910.3;NM_016834.2;NM_016835.2;NM_016841.2

Alternate Names for Tau Antibody (tau-C3)

• DDPAC
• FLJ31424
• FTDP-17
• G protein beta1/gamma2 subunit-interacting factor 1
• MAPT
• MGC138549
• microtubule-associated protein tau
• MSTD
• MSTDMAPTL
• MTBT1
• MTBT1Neurofibrillary tangle protein
• MTBT2
• Neurofibrillary tangle protein
• PHF-tau
• PPND
• Tau
• TAUPaired helical filament-tau

Background

Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Tau's association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for Tau Antibody (NBP2-29847). (Showing 1 - 1 of 1 FAQ).

1. What is the immunogen sequence used to generate this antibody?
   • The immunogen for NBP2-29847, Tau Antibody (tau-C3) is aa 412-421 of the human Tau protein. This clone specifically reacts with Tau, caspase cleaved (truncated at Asp421).

Bioinformatics

• Gene Symbol: MAPT
• Uniprot:
  • P10636()