TAO Kinase 1 Antibody (TAO1 1.2) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Applications: WB, ICC/IF, Mycoplasma
• Clone: TAO1 1.2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

TAO Kinase 1 Antibody (TAO1 1.2) [Alexa Fluor™ Plus 488] Summary

• Immunogen: His-tagged recombinant human TAO Kinase 1 (722-1001) generated in E.coli
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: TAOK1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Knockdown Validated
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TAO Kinase 1 Antibody (TAO1 1.2) [Alexa Fluor™ Plus 488]

• EC 2.7.11
• FLJ14314
• hKFC-B
• hTAOK1
• KIAA1361
• KIAA1361STE20-like kinase PSK2
• Kinase from chicken homolog B
• MAP3K16
• MAP3K16EC 2.7.11.1
• MARK Kinase
• MARKK
• MARKKmicrotubule affinity regulating kinase kinase
• PSK2
• PSK-2
• PSK2serine/threonine kinase TAO1
• serine/threonine-protein kinase TAO1
• TAO Kinase 1
• TAO1serine/threonine protein kinase TAO1 homolog
• TAOK1
• Thousand and one amino acid protein 1

Background

TAOK1, a member of the Ste20 kinase family, is a TAO type protein kinase that acts as an upstream activator to MARK by phosphorylation. When activated, MARK enhances microtubule dynamics and leads to phosphorylation and detachment of tau or equivalent MAPs from microtubules. Overexpression of MARK eventually leads to microtubule breakdown and cell death, but in neuronal cells the primary effect is to allow the development of neurites during differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TAOK1