TAK1 Antibody

Product Discontinued

TAK1 Antibody Summary

• Immunogen: Peptide with sequence C-AELDQDEKDQQNT corresponding to internal region according to NP_003179.1, NP_663304.1.
• Specificity: This antibody is expected to recognise isoform A (NP_003179.1) and isoform B (NP_663304.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: MAP3K7
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:8000
  • Western Blot 1 - 2 ug/ml
• Application Notes: WB: In transfected HEK293 transiently expressing full-length human MAP3K7 (myc and DYKDDDDK tagged), a band of approx. 75 kDa band was observed. No bands were observed in mock-transfected HEK293 and the same band was observed using anti-DYKDDDDK tag antibody.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for TAK1 Antibody

• EC 2.7.11
• EC 2.7.11.25
• MAP3K7
• MEKK7
• mitogen-activated protein kinase kinase kinase 7
• TAK1
• TAK1/MAP3K7
• TAK1TGF1a
• TGF1a
• TGF-beta activated kinase 1
• TGF-beta-activated kinase 1
• Transforming growth factor-beta-activated kinase 1

Background

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TAK1 Antibody (NB100-40797)(1)

Publication using NB100-40797

• Omori E, Matsumoto K, Sanjo H et al. TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J Biol Chem 2006-05-04 [PMID: 16675448]

Bioinformatics

• Gene Symbol: MAP3K7
• Entrez:
  • 6885(Human)
  • 26409(Mouse)
• Uniprot:
  • NP_003179.1(Human)