Synapsin I [p Ser62, p Ser67] Antibody

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Western Blot: Synapsin I [p Ser62, p Ser67] Antibody [NB300-745] - Western blot of rat cortex lyaste showing specific labeling of the ~78k Synapsin protein phosphorylated at Ser62,67 (Control). Immunolabeling is blocked ...read more

Product Details

Summary
Reactivity Rt, Mu, BvSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Synapsin I [p Ser62, p Ser67] Antibody Summary

Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phosphoSer62,67 of synapsin I.
Modification
p Ser62, p Ser67
Localization
Cell junction; synapse
Marker
pre-Synaptic Marker
Specificity
Specific for ~78k synapsin I doublet phosphorylated at Ser62,67. Immunolabeling of the synapsin I band is blocked by preadsorption with the phospho-peptide used as antigen but not be the corresponding dephospho-peptide.
Predicted Species
Mouse (100%), Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SYN1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for Synapsin I [p Ser62, p Ser67] Antibody

  • phospho Synapsin
  • SYN1
  • SYN1a
  • SYN1b
  • Synapsin 1
  • Synapsin I
  • synapsin IBrain protein 4.1
  • synapsin-1
  • SYNI

Background

Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Ser 549 along with Ser 62 and Ser 67 are the sites of Synapsin I that are phosphorylated by MAP kinase (Czernik et al., 1987; Jovanovic et al., 1996).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Blogs on Synapsin I.

Synapsin I, a pre-synaptic marker
Synapsin-I, also called Synapsin 1/Syn1, is an ~80 kDa protein (predicted mol. wt. 74.1 kDa) which belongs to the Synapsin family (Synapsin I, Synapsin II, Synapsin III). Synapsins are the evolutionarily conserved phospho-proteins which are associ...  Read full blog post.

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Bioinformatics

Gene Symbol SYN1
Entrez
Uniprot