SUV420h1 Antibody


Immunocytochemistry/ Immunofluorescence: SUV420h1 Antibody [NBP1-97312] - SUV420h1 antibody was tested in A431 cells with FITC (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 more
Immunohistochemistry: SUV420h1 Antibody [NBP1-97312] - IHC analysis of SUV420h1 in mouse epidermis using DAB with hematoxylin counterstain.

Product Details

Reactivity Hu, MuSpecies Glossary
Applications ICC/IF, IHC, IHC-P, WB (-)
1.14 mg/ml

SUV420h1 Antibody Summary

A synthetic peptide made to an internal portion of the human SUV420h1 protein (between residues 100-150) [UniProt Q4FZB7]
Nucleus. Chromosome. Note: Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS, 30% glycerol
0.05% Sodium Azide
1.14 mg/ml
Immunogen affinity purified


Application Notes
This SUV420h1 antibody is useful for Immunocytochemistry/Immunofluorescence and IHC-paraffin embedded sections. In ICC/IF, nuclear staining was observed in A431 cells. In IHC-P, staining was observed in the nucleus of mouse epidermis tissue. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. This antibody is not recommended for Western Blot.

Reactivity Notes

Human and mouse.

Alternate Names for SUV420h1 Antibody

  • C630029K18Rik
  • CGI85
  • CGI-85
  • EC
  • histone-lysine N-methyltransferase SUV420H1
  • KMT5B Lysine N-methyltransferase 5B
  • KMT5B
  • MGC118906
  • MGC118909
  • MGC21161
  • MGC703
  • Su(var)4-20 homolog 1
  • suppressor of variegation 4-20 homolog 1 (Drosophila)
  • Suppressor of variegation 4-20 homolog 1
  • suv4-20h1


SUV420H1 (Histone-lysine N-methyltransferase 5B, KMT5B) is a histone methyltransferase that specifically di- and trimethlyates lysine 20 of H4 (H4 K20Me3), an epigenetic mark of transcriptional repression. This mark, along with trimethylation of histone 3 lysine 9 (H3 K9me3) and monomethylation of H3 lysine 27 (H3 K27me1), define genomic regions of constitutive heterochromatin that are poor in activated genes. This enzyme is essential for development, with Suv420h1 knockout mice proving lethal perinatally and showing overall growth retardation. The RB1 family of proteins have been shown to interact with, and target, KMT5B to histones, enabling the enzyme to function.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

View specific protocols for SUV420h1 Antibody (NBP1-97312): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NBP1-97312AF405
Alexa Fluor (R) 488 Labeled NBP1-97312AF488
Alexa Fluor (R) 647 Labeled NBP1-97312AF647
Alexa Fluor (R) 700 Labeled NBP1-97312AF700
Biotin Labeled NBP1-97312B
DyLight 405 Labeled NBP1-97312V
DyLight 488 Labeled NBP1-97312G
DyLight 550 Labeled NBP1-97312R
DyLight 650 Labeled NBP1-97312C
FITC Labeled NBP1-97312F
HRP Labeled NBP1-97312H

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Contact Information

Product PDFs


Gene Symbol SUV420H1

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