Suppressor of Fused Antibody

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Immunoprecipitation: Suppressor of Fused Antibody [NBP1-28703] - Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-SuFu antibody NBP1-28703 used for ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-28703
    • Availability
      Product Discontinued

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Suppressor of Fused Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 325 and 375 of human suppressor of fused homolog using the numbering given in entry NP_057253.2 (GeneID 51684).
Clonality
Polyclonal
Host
Rabbit
Gene
SUFU
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunoprecipitation 2-5 ug/mg lysate
Application Notes
This antibody is useful for immunoprecipitation. It is not recommended for western analysis.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Suppressor of Fused Antibody

  • SUFUHSUFUXLPRO1280
  • suppressor of fused homolog (Drosophila)
  • suppressor of fused homolog

Background

Suppressor of fused (SuFu) is a negative regulator of the hedgehog and beta-catenin signaling pathway. It down-regulates GLI1-mediated transactivation of target genes and is part of a corepressor complex that acts on DNA-bound GLI1. SuFu may also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Additionally, SuFu sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Diseases for Suppressor of Fused Antibody (NBP1-28703)

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Bioinformatics

Gene Symbol SUFU
Entrez
Uniprot