Suppressor of Fused Products

Antibodies
Suppressor of Fused Antibody
Suppressor of Fused Antibody
NBP2-20536
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Suppressor of Fused Antibody
Suppressor of Fused Antibody
NBP1-87384
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Suppressor of Fused Antibody ...
Suppressor of Fused Antibody (1B2)
H00051684-M01
Species: Hu
Applications: ELISA, PLA
Host: Mouse Monoclonal
Lysates
Suppressor of Fused Overexpre ...
Suppressor of Fused Overexpression...
NBL1-16597
Applications: WB
Suppressor of Fused Overexpre ...
Suppressor of Fused Overexpression...
H00051684-T02
Applications: WB
Proteins
Suppressor of Fused Recombina ...
Suppressor of Fused Recombinant Pr...
NBP1-87384PEP
Species: Hu
Applications: AC
Suppressor of Fused Recombina ...
Suppressor of Fused Recombinant Pr...
NBP1-72463
Species: Hu
Applications: PAGE
RNAi
Suppressor of Fused RNAi
Suppressor of Fused RNAi
H00051684-R01
Species: Hu

Description

The Hedgehog (Hh) signaling pathway has conserved roles in development of species ranging from Drosophila to humans. Human supressor of fused HSu(Fu) acts as a negative regulator in the hedgehog signaling (SHH) pathway by down-regulating GLI1-mediated transactivation of target genes (1). HSu(fu) was found to repress activity of the zinc-finger transcription factor Gli, which mediates Hedgehog signaling in vertebrates, and to physically interact with Gli, Gli2 and Gli3 (2). The sonic hedgehog signaling pathway directs the embryonic development of diverse organisms and is disrupted in a variety of malignancies. Several of mutations encode truncated proteins that are unable to export the GLI transcription factor from nucleus to cytoplasm, resulting in the activation of SHH signaling. SUFU is a newly identified tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway through a newly identified mechanism (3).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 51684
Alternate Names
  • suppressor of fused homolog
  • SUFUHSUFUXLPRO1280
  • suppressor of fused homolog (Drosophila)

PTMs for Suppressor of Fused

Learn more about PTMs related to Suppressor of Fused.

Phosphorylation
Cleavage
Methylation
Ubiquitination
Reduction
Dephosphorylation

Bioinformatics Tool for Suppressor of Fused

Discover related pathways, diseases and genes to Suppressor of Fused. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.