Suppressor of Fused Products

Antibodies
Suppressor of Fused Antibody
Suppressor of Fused Antibody
NBP1-87384
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Suppressor of Fused Antibody
Suppressor of Fused Antibody
H00051684-D01P
Species: Hu
Applications: WB, Func
Host: Rabbit Polyclonal
Lysates
Suppressor of Fused Overexpre ...
Suppressor of Fused Overexpression...
NBL1-16597
Species: Hu
Applications: WB
Proteins
Recombinant Human Suppressor ...
Recombinant Human Suppressor of Fu...
NBP1-72463
Species: Hu
Applications: PAGE
Suppressor of Fused Recombina ...
Suppressor of Fused Recombinant Pr...
NBP1-87384PEP
Species: Hu
Applications: AC

Description

The Hedgehog (Hh) signaling pathway has conserved roles in development of species ranging from Drosophila to humans. Human supressor of fused HSu(Fu) acts as a negative regulator in the hedgehog signaling (SHH) pathway by down-regulating GLI1-mediated transactivation of target genes (1). HSu(fu) was found to repress activity of the zinc-finger transcription factor Gli, which mediates Hedgehog signaling in vertebrates, and to physically interact with Gli, Gli2 and Gli3 (2). The sonic hedgehog signaling pathway directs the embryonic development of diverse organisms and is disrupted in a variety of malignancies. Several of mutations encode truncated proteins that are unable to export the GLI transcription factor from nucleus to cytoplasm, resulting in the activation of SHH signaling. SUFU is a newly identified tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway through a newly identified mechanism (3).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Alternate Names
  • SUFUHSUFUXLPRO1280
  • suppressor of fused homolog (Drosophila)
  • suppressor of fused homolog