SUCNR1/GPR91 Antibody

Western Blot: SUCNR1/GPR91 Antibody [NBP3-27860] - Western blot analysis of lysates from HUVEC and MCF-7 cells, using NBP3-27860. The lane on the right is blocked with the synthesized peptide.

• Reactivity: Hu, Mu, Rt, Po
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

SUCNR1/GPR91 Antibody Summary

• Description: Novus Biologicals Rabbit SUCNR1/GPR91 Antibody (NBP3-27860) is a polyclonal antibody validated for use in WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: The antiserum was produced against synthesized peptide derived from human SUCNR1/GPR91. (Uniprot #: Q9BXA5)
• Specificity: Detects endogenous levels of SUCNR1/GPR91
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SUCNR1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Western Blot 1:500 - 1:2000
• Theoretical MW: 38 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS, 50% glycerol, 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Purity: Antigen Affinity-purified

Alternate Names for SUCNR1/GPR91 Antibody

• GPR91
• GPR91G protein-coupled receptor 91
• G-protein coupled receptor 91
• P2Y purinoceptor 1
• P2Y purinoceptor 1-like
• succinate receptor 1
• SUCNR1

Background

GPR91 (formerly known as P2U2) is a G protein-coupled, dicarboxylic acid succinate receptor. It has a high level of expression in the kidney, predominantly in the proximal tubules, and localizes to the plasma membrane. It has also been found at low levels in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate: Arg 99, His 103, Arg 252 and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure and atherosclerosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SUCNR1