SUCNR1/GPR91 Products

Antibodies
SUCNR1/GPR91 Antibody
SUCNR1/GPR91 Antibody
NBP2-24549
Species: Hu, Pm
Applications: WB, IHC-P
Host: Rabbit Polyclonal
SUCNR1/GPR91 Antibody
SUCNR1/GPR91 Antibody
NBP2-26239
Species: Hu, Pm
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
SUCNR1/GPR91 Overexpression L ...
SUCNR1/GPR91 Overexpression Lysate...
NBL1-16595
Applications: WB
Proteins
SUCNR1/GPR91 Recombinant Prot ...
SUCNR1/GPR91 Recombinant Protein
H00056670-G01
Species: Hu
RNAi
SUCNR1/GPR91 RNAi
SUCNR1/GPR91 RNAi
H00056670-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

GPR91 (formerly known as P2U2) is a G protein-coupled, dicarboxylic acid succinate receptor. It has a high level of expression in the kidney, predominantly in the proximal tubules, and localizes to the plasma membrane. It has also been found at low levels in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate: Arg 99, His 103, Arg 252 and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure and atherosclerosis.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Product By Gene ID 56670
Alternate Names
  • P2Y purinoceptor 1-like
  • P2Y purinoceptor 1
  • G-protein coupled receptor 91
  • GPR91G protein-coupled receptor 91
  • succinate receptor 1

Pathways for SUCNR1/GPR91

View related products by pathway and learn more about each of the pathways below.

Platelet Activation
Platelet Aggregation
Receptor Internalization
Localization

Research Areas for SUCNR1/GPR91

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GPCR

PTMs for SUCNR1/GPR91

Learn more about PTMs related to SUCNR1/GPR91.

Phosphorylation

Bioinformatics Tool for SUCNR1/GPR91

Discover related pathways, diseases and genes to SUCNR1/GPR91. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related SUCNR1/GPR91 Blog Posts

Check out the latest blog posts on SUCNR1/GPR91.
SUCNR1/GPR91 - a potential role in renovascular hypertension
SUCNR1 is the cognate receptor for the Kreb's citric acid cycle intermediate succinate. It is of interest to scientists because it is involved in not only energy metabolism but possibly also in renovascular hypertension, a condition linked to diabe...    Read more.
Read more SUCNR1/GPR91 related blogs.