SUCNR1/GPR91 Products


GPR91 (formerly known as P2U2) is a G protein-coupled, dicarboxylic acid succinate receptor. It has a high level of expression in the kidney, predominantly in the proximal tubules, and localizes to the plasma membrane. It has also been found at low levels in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate: Arg 99, His 103, Arg 252 and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure and atherosclerosis.


Entrez Human
Uniprot Human
Product By Gene ID 56670
Alternate Names
  • P2Y purinoceptor 1-like
  • P2Y purinoceptor 1
  • G-protein coupled receptor 91
  • GPR91G protein-coupled receptor 91
  • succinate receptor 1

Pathways for SUCNR1/GPR91

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Platelet Activation
Platelet Aggregation
Receptor Internalization

Research Areas for SUCNR1/GPR91

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Bioinformatics Tool for SUCNR1/GPR91

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Related SUCNR1/GPR91 Blog Posts

Check out the latest blog posts on SUCNR1/GPR91.
SUCNR1/GPR91 - a potential role in renovascular hypertension
SUCNR1 is the cognate receptor for the Kreb's citric acid cycle intermediate succinate. It is of interest to scientists because it is involved in not only energy metabolism but possibly also in renovascular hypertension, a condition linked to diabe...    Read more.
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