STEP Antibody

Product Discontinued

STEP Antibody Summary

• Immunogen: PTPN5 (NP_008837.1, 1 a.a. ~ 565 a.a) full-length human protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PTPN5
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: This antibody is useful for Western Blot

Reactivity Notes

This product is reactive against Human,Mouse.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for STEP Antibody

• EC 3.1.3.48
• FLJ14427
• Neural-specific protein-tyrosine phosphatase
• protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
• protein-tyrosine phosphatase striatum-enriched
• PTPN5
• STEP
• STEPPTPSTEP
• Striatum-enriched protein-tyrosine phosphatase
• tyrosine-protein phosphatase non-receptor type 5

Background

Tyrosine phosphorylation plays a critical role in many physiological processes. There is a fine balance between phosphorylation caused by protein tyrosine kinases and actions of protein tyrosine phosphatases, that regulates these physiological processes. Striatal enriched phosphatase (STEP) is part of a family of protein tyrosine phosphatases enriched within the CNS and is a component of the NMDAR complex. It is expressed within dopaminoceptive neurons in the CNS and particularly enriched within the basal ganglia and related structures. STEP61 is a membrane-associated isoform and STEP46 is a cytosolic protein. In response to transient hypoxia-ischemia in the brain, STEP61 is proteolytically cleaved by calpain, thereby releasing a smaller isoform, STEP33.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPN5
• Uniprot:
  • NP_008837.1(Human)