STEP Products

Antibodies
STEP Antibody (23E5)
STEP Antibody (23E5)
NB300-202
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr, IP
Host: Mouse Monoclonal
STEP Antibody
STEP Antibody
NBP1-87186
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
STEP Antibody
STEP Antibody
NBP1-33388
Species: Hu, Mu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
STEP Antibody Pair
STEP Antibody Pair
H00084867-AP21
Species: Hu
Applications: S-ELISA
STEP Antibody Pair
STEP Antibody Pair
H00084867-PW1
Species: Hu
Applications: WB, IP
Lysates
STEP Overexpression Lysate (D ...
STEP Overexpression Lysate (Denatu...
H00084867-T01
Species: Hu
Applications: WB
STEP Overexpression Lysate (N ...
STEP Overexpression Lysate (Native)
NBP2-11299
Applications: WB
STEP Overexpression Lysate (N ...
STEP Overexpression Lysate (Native)
NBL1-14975
Applications: WB
Proteins
Recombinant Human STEP Protei ...
Recombinant Human STEP Protein
H00084867-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human STEP Protei ...
Recombinant Human STEP Protein
H00084867-Q01
Species: Hu
Applications: WB, ELISA, PA
STEP Recombinant Protein Anti ...
STEP Recombinant Protein Antigen
NBP2-58008PEP
Species: Hu
Applications: AC
RNAi
STEP RNAi
STEP RNAi
H00084867-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The protein tyrosine phosphatase non-receptor type 5 or striatum-enriched protein-tyrosine phosphatase (STEP) protein is part of a family of protein tyrosine phosphatases enriched within the CNS, and is a key component of the NMDAR complex. It is expressed within dopaminoceptive neurons in the CNS and particularly enriched within the basal ganglia and related structures. STEP61 is the membrane-associated isoform and STEP46 is the cytosolic protein. In response to transient hypoxia-ischemia in the brain, STEP61 is proteolytically cleaved by calpain, thereby releasing a smaller isoform, STEP33.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 84867
Alternate Names
  • EC 3.1.3.48
  • tyrosine-protein phosphatase non-receptor type 5
  • Striatum-enriched protein-tyrosine phosphatase
  • protein-tyrosine phosphatase striatum-enriched
  • Neural-specific protein-tyrosine phosphatase
  • STEPPTPSTEP
  • FLJ14427
  • protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)

Research Areas for STEP

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Cancer
Cellular Markers
Hypoxia
Neurodegeneration
Neuroscience
Protein Phosphatase
Signal Transduction

PTMs for STEP

Learn more about PTMs related to STEP.

Phosphorylation
Dephosphorylation
Cleavage
Ubiquitination
Biotinylation

Bioinformatics Tool for STEP

Discover related pathways, diseases and genes to STEP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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