SRPK2 Antibody [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 488

SRPK2 Antibody [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human SRPK2
  Asn313-Ala466
  Accession # P78362
• Specificity: Detects endogenous human SRPK2 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SRPK2 Antibody [Alexa Fluor® 488]

• EC 2.7.11.1
• FLJ36101
• H_RG152G17.1a
• H_RG152G17.1b
• serine kinase SRPK2
• Serine/arginine-rich protein-specific kinase 2
• serine/arginine-rich splicing factor kinase 2
• serine/threonine-protein kinase SRPK2
• SFRS protein kinase 2SFRSK2
• SFRSK2
• SR protein kinase 2
• SRPK2
• SR-protein-specific kinase 2
• SRSF protein kinase 2
• WUGSC:H_RG152G17.1a

Background

SRPK2 (Ser/Arg-rich protein specific kinase 2) is a cytoplasmic, 115‑120 kDa member of the CMGC Ser/Thr protein kinase family of enzymes. It is expressed in many experimental cell lines and serves to selectively phosphorylate Ser on RS domain-containing proteins. This phosphorylation activates RS domain-containing non-snRNP proteins in the spliceosome complex, and initiates mRNA splicing. Human SRPK2 is 688 amino acids (aa) in length. It contains a Pro-rich region (aa 21‑45) that may interact with WW domain-containing proteins, and a split kinase domain (aa 79‑226 and 524‑646). Phosphorylation on S52 and S588 regulates activity. There are at least two splice variants. One shows a 24 aa substitution for aa 1‑13, while a second shows a nine aa substitution for aa 538‑688.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.