SLITRK5 Antibody (310516) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clone: 310516
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

SLITRK5 Antibody (310516) [Alexa Fluor® 647] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human SLITRK5
  Glu39-Val665
  Accession # O94991
• Specificity: Detects human SLITRK5 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human SLITRK1, 2, 3, or 4 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SLITRK5 Antibody (310516) [Alexa Fluor® 647]

• bA364G4.2
• FLJ58374
• KIAA0918
• leucine-rich repeat-containing protein 11
• LRRC11
• SLIT and NTRK-like family, member 5
• SLIT and NTRK-like protein 5
• SLITRK5

Background

SLITRK5 (Slit and Trk-like family member 5; also named LRR-containing protein 11) is a member of the SLITRK family of proteins (1, 2). This family currently includes six members, all of which contain a slit-like extracellular region and (save for SLITRK1) a Trk-like cytoplasmic region (3). Human SLITRK5 is a type I transmembrane (TM) protein that is 958 amino acids (aa) in length. It contains a putative 40 aa signal sequence, a 624 aa extracellular domain (ECD), a 21 aa TM segment, and a 273 aa cytoplasmic region. The ECD is characterized by the presence of two leucine-rich domains (LRD) that resemble those found in slit. Each LRD (aa 80‑285 plus aa 384‑579) contains seven and eight leucine-rich repeats (LRRs), respectively. Based on other LRRs, it is likely that the LRRs mediate protein-protein-interaction (4). The cytoplasmic region contains two conserved, potential phosphorylation sites at Tyr833 and Tyr917, plus a TrkA-like tyrosine phosphorylation site (YLxxL) at Tyr945. SLITRK5 is expressed on embryonic neurons of the hippocampus (pyramidal layer) and thalamus (3). Based on SLITRK2 studies, SLITRK5 will block neurite extension (3). SLITRK5 is markedly upregulated in many neurological tumors. Human SLITRK5 shares 97% and 98% aa identity with mouse and canine SLITRK5, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.