SLC4A8 Antibody

Product Discontinued

SLC4A8 Antibody Summary

• Immunogen: Peptide with sequence TNLEVKNGVNCEH corresponding to internal region according to NP_004849.2.
• Epitope: TNLEVKNGVNCEH
• Specificity: This antibody is expected to recognize isoform a and b (NP_001035049.1; NP_004849.2).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SLC4A8
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:1000
• Application Notes: WB: Preliminary experiments in human brain (cerebellum), mouse brain and rat brain lysates, and in lysates of human breast cancer, human kidney and human lymph node gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for SLC4A8 Antibody

• DKFZp761B2318
• Electroneutral Na(+)-driven Cl-HCO3 exchanger
• FLJ46462
• KIAA0739
• k-NBC3
• Na+-driven Cl-HCO3 exchanger
• NBC
• NBC3electroneutral sodium bicarbonate exchanger 1
• NDCBE
• NDCBE1
• Solute carrier family 4 member 8
• solute carrier family 4, sodium bicarbonate cotransporter, member 8

Background

SLC4A8 mediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SLC4A8 Antibody (NBP1-52161)(1)

Publication using NBP1-52161

• Parker MD, Bouyer P, Daly CM, Boron WF. Cloning and characterization of novel human SLC4A8 gene products encoding Na+-driven Cl-/HCO3(-) exchanger variants NDCBE-A, -C, and -D. Physiol Genomics 2008-08-15 [PMID: 18577713]

Bioinformatics

• Gene Symbol: SLC4A8
• Entrez:
  • 9498(Human)
  • 59033(Mouse)
  • 315311(Rat)
• Uniprot:
  • NP_001035049.1(Human)