SLC39A4/ZIP4 Antibody [CoraFluor™ 1]

CoraFluor™ 1, amine reactive (Catalog:7920) and CoraFluor™ 2, amine reactive (Catalog # 7950) are terbium-based probes that have been developed for use as TR-FRET donors. They emit wavelengths compatible with commonly used fluorescent acceptor dyes such as BODIPY® (or BDY) and Janelia Fluor® dyes, FITC (Catalog # 5440), TMR and Cyanine 5 (Catalog # 5436). CoraFluor™ fluorescence is brighter and more stable in biological media than existing TR-FRET donors, leading to enhanced sensitivity and improved data generation. CoraFluor™ 1 exhibits excitation upon exposure to a 337 nm UV laser.

• Reactivity: Mu
• Applications: WB, Flow, IHC, CyTOF-ready
• Clonality: Polyclonal
• Host: Goat
• Conjugate: CoraFluor 1

SLC39A4/ZIP4 Antibody [CoraFluor™ 1] Summary

• Description: CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(TM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
  
  CoraFluor(TM) 1, amine reactive
  
  CoraFluor(TM) 1, thiol reactive
  
  For more information, please see our CoraFluor(TM) TR-FRET technology flyer.
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse SLC39A4
  Met1-Tyr337
  Accession # Q78IQ7
• Specificity: Detects mouse SLC39A4 in direct ELISAs.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SLC39A4
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Antigen Affinity-purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for SLC39A4/ZIP4 Antibody [CoraFluor™ 1]

• acrodermatitis enteropathica, zinc-deficiency type
• AEZ
• FLJ20327
• MGC74741
• SLC39A4
• solute carrier family 39 (zinc transporter), member 4
• Solute carrier family 39 member 4
• zinc transporter ZIP4
• ZIP4
• ZIP-4
• ZIP4AEZ
• Zrt- and Irt-like protein 4

Background

SLC39A4/ZIP4 is a gene that codes for a protein that plays a role as a zinc transporter in cellular zinc homeostasis and has two isoforms, with lengths of 647 and 622 amino acids and weights of approximately 68 and 66 kDa respectively. Current research is being done on several diseases and disorders related to this gene including enteropathica, autosomal recessive disease, mental disorders, alopecia, diarrhea, dermatitis, pancreatic cancer, pancreatitis, and carcinoma. SLC39A$/ZIP4 has also been shown to be incvolved in pathways such as the senescence and autophagy, metal ion SLC transporters, and mineral absorption pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLC39A4