Sirtuin 2/SIRT2 Antibody [Alexa Fluor™ Plus 647]

• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor Plus 647

Sirtuin 2/SIRT2 Antibody [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human Sirtuin 2/SIRT2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human SIRT1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Sirtuin 2/SIRT2 Antibody [Alexa Fluor™ Plus 647]

• EC 3.5.1
• EC 3.5.1.-
• FLJ35621
• FLJ37491
• S.cerevisiae, homolog) 2
• SIR2L2
• SIRT2
• Sirtuin 2
• sirtuin type 2

Background

Sirtuin 2, encoded by the SIRT2 gene, is also known as SIR2 (silent information regulator 2)-like protein 2. It is a nicotinamide adenine dinucleotide (NAD)-dependent histone/protein deacetylase (1‑2). The SIR2 family of enzymes is classified as class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging (3‑4). Unlike class I and class II HDACs, the enzymatic activity of class III HDACs is NAD dependent and insensitive to HDAC inhibitor trichostatin A (5).

1. Frye, R.A. (1999) Biochem. Biophys. Res. Commun. 260:273.
2. North, B.J. et al. (2003) Mol. Cell. 11:437.
3. North, B.J. and Verdin, E. (2004) Genome Biol. 5:224.
4. Marmorstein, R. (2004) Biochem. Soc. Trans. 32:904.
5. Gray, S.G. and Ekstrom, T.J. (2001) Exp. Cell Res. 262:75.  

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.