Sirtuin 2/SIRT2 Products

Antibodies
Sirtuin 2/SIRT2 Antibody
Sirtuin 2/SIRT2 Antibody
NBP1-76879
Species: Hu, Mu, Rt, Rb
Applications: WB, ELISA, IHC, IHC-P, ICC/IF
Host: Rabbit Polyclonal
Sirtuin 2/SIRT2 Antibody
Sirtuin 2/SIRT2 Antibody
NBP1-87039
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Sirtuin 2/SIRT2 Antibody (4B1 ...
Sirtuin 2/SIRT2 Antibody (4B11)
H00022933-M01
Species: Hu
Applications: WB, ELISA, ICC/IF, RNAi, S-ELISA
Host: Mouse Monoclonal
Kits
Sirtuin 2/SIRT2 Assay Kit (Fl ...
Sirtuin 2/SIRT2 Assay Kit (Fluorom...
KA1368
Applications: Func
Lysates
Sirtuin 2/SIRT2 Overexpressio ...
Sirtuin 2/SIRT2 Overexpression Lysate
NBL1-15974
Species: Hu
Applications: WB
Proteins
Recombinant Human Sirtuin 2/S ...
Recombinant Human Sirtuin 2/SIRT2 ...
4358-DA
Species: Hu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Sirtuin 2/SIRT2 Recombinant P ...
Sirtuin 2/SIRT2 Recombinant Protei...
NBP1-87039PEP
Species: Hu
Applications: AC
Sirtuin 2/SIRT2 Antibody Bloc ...
Sirtuin 2/SIRT2 Antibody Blocking ...
NBP1-76879PEP
Species: Hu
Applications: AC

Description

Silent information regulator 2 (Sir2) family of enzymes has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging. O-acetyl-ADP-ribose causes a delay/block in oocyte maturation and results in a delay/block in embryo cell division in blastomeres. It has been demonstrated that the production of O-acetyl-ADP-ribose is evolutionarily conserved among Sir2-like enzymes from yeast, Drosophila, and human. Also, endogenous yeast Sir2 complex from telomeres was shown to generate O-acetyl-ADP-ribose (1). SIRT2 is a predominantly cytoplasmic protein that colocalizes with microtubules. SIRT2 deacetylates lysine-40 of alpha-tubulin both in vitro and in vivo. Knockdown of SIRT2 via siRNA results in tubulin hyperacetylation. SIRT2 colocalizes and interacts in vivo with HDAC6, another tubulin deacetylase (2). Cytoskeleton-related protein, SIRT2 is down-regulated in gliomas, and data suggests that ectopic expression of SIRT2 in glioma cell lines led to the perturbation of the microtubule network (3).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 22933
Alternate Names
  • EC 3.5.1
  • FLJ37491
  • EC 3.5.1.-
  • FLJ35621
  • sirtuin type 2
  • S.cerevisiae, homolog) 2
  • sirtuin 2

Research Areas for Sirtuin 2/SIRT2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Chromatin Research
DNA Repair
Epigenetics
Histone Deacetylases
Neuronal Cell Markers
Transcription Factors and Regulators

Bioinformatics Tool for Sirtuin 2/SIRT2

Discover related pathways, diseases and genes to Sirtuin 2/SIRT2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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