Hu, Mu, Rt, RbApplications:
WB, ELISA, IHC, IHC-P, ICC/IFHost:
Applications: WB, Flow, ICC/IF, PA
Host: Mouse Monoclonal
WB, ICC/IF, IHC, IHC-PHost:
Applications: Enzyme Activity
Silent information regulator 2 (Sir2) family of enzymes has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging. O-acetyl-ADP-ribose causes a delay/block in oocyte maturation and results in a delay/block in embryo cell division in blastomeres. It has been demonstrated that the production of O-acetyl-ADP-ribose is evolutionarily conserved among Sir2-like enzymes from yeast, Drosophila, and human. Also, endogenous yeast Sir2 complex from telomeres was shown to generate O-acetyl-ADP-ribose (1). SIRT2 is a predominantly cytoplasmic protein that colocalizes with microtubules. SIRT2 deacetylates lysine-40 of alpha-tubulin both in vitro and in vivo. Knockdown of SIRT2 via siRNA results in tubulin hyperacetylation. SIRT2 colocalizes and interacts in vivo with HDAC6, another tubulin deacetylase (2). Cytoskeleton-related protein, SIRT2 is down-regulated in gliomas, and data suggests that ectopic expression of SIRT2 in glioma cell lines led to the perturbation of the microtubule network (3).
Bioinformatics Tool for Sirtuin 2/SIRT2
Discover related pathways, diseases and genes to Sirtuin 2/SIRT2. Need help? Read the Bioinformatics Tool Guide
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