Siglec-1/CD169 Antibody (HSn 7D2) [FITC]

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Product Details

Summary
Reactivity Hu, Po, ViSpecies Glossary
Applications ELISA, Flow, IHC-Fr, IHC-P
Clone
HSn 7D2
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Siglec-1/CD169 Antibody (HSn 7D2) [FITC] Summary

Immunogen
Full-length purified human Sialoadhesin (d1-4)Fc protein. [Swiss-Prot# Q9BZZ2]
Epitope
Within domains 1-4.
Localization
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SIGLEC1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This Sialoadhesin Antibody (HSn 7D2) is useful for Immunohistochemistry (paraffin-embedded, acetone-fixed, and frozen sections), Flow Cytometry, Radioimmunoassay and ELISA. Western Blot was reported in scientific literature. Use in in vitro assay reported in scientific literature ( PMID 18414664)

Reactivity Notes

Human. Porcine reactivity reported in scientific literature (PMID: 27441395). Virus reactivity reported in scientific literature (PMID: 27487279). Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Siglec-1/CD169 Antibody (HSn 7D2) [FITC]

  • CD169
  • FLJ00051
  • sialic acid binding Ig-like lectin 1, sialoadhesin
  • sialoadhesin

Background

Sialoadhesin, also known as sialic acid-binding Ig-like lectin 1, siglec-1, CD169, SIGLEC1, and SN, is a member of the sialic acid binding Ig-like lectin (SIGLEC) family. The SIGLECs are a family of membrane bound lectins that belong to the immunoglobulin superfamily. SIGLECs bind sialic acid and mediate cell to cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a lectin-like macrophage-specific cell adhesion molecule that mediates sialic acid dependent binding of glycoconjugate ligands on activated macrophages, lymphocytes, granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. The Sialoadhesin protein is found in two locations within the cell, the cell membrane (isoform 1) and secreted in the cytoplasm (isoform 2). Sialoadhesin is expressed in spleen, lymph node, brain, bone marrow, liver, colon and lung tissues and in inflammatory macrophages in rheumatoid arthritis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB600-534APC
DyLight 350 Labeled NB600-534UV
DyLight 405 Labeled NB600-534V
DyLight 488 Labeled NB600-534G
DyLight 680 Labeled NB600-534FR
DyLight 755 Labeled NB600-534IR
PE Labeled NB600-534PE
PerCP Labeled NB600-534PCP

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Bioinformatics

Gene Symbol SIGLEC1