SET Antibody


Western Blot: SET Antibody [NBP1-33713] - Western blot analysis of SET on Molt-4 lysates using NBP1-33713 at a dilution of 1:1000. 30 ug whole cell lysate loaded on 12% SDS PAGE gel.
Immunocytochemistry/ Immunofluorescence: SET Antibody [NBP1-33713] - Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using SET (NBP1-33713) antibody at 1:200 dilution.
Immunohistochemistry-Paraffin: SET Antibody [NBP1-33713] - Immunohistochemical analysis of SET on paraffin-embedded DLD-1 xenograft, using NBP1-33713.

Product Details

Reactivity Hu, Mu, Rt, Chicken, PorcineSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
0.43 mg/ml

Order Details

SET Antibody Summary

Recombinant fragment corresponding to a region within amino acids 1 and 210 of SET.
Cytoplasm, cytosol, Endoplasmic reticulum, Nucleus, nucleoplasm
Predicted Species
Porcine (100%), Chicken (100%). Backed by our 100% Guarantee.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
0.01% Thimerosal
0.43 mg/ml
Immunogen affinity purified


  • Western Blot 1:500-1:3000
  • Immunocytochemistry/Immunofluorescence 1:100-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:100-1:500
Application Notes
Antibody reactive against recombinant protein, detects immunogen. Further validation in progress.

Reactivity Notes

Human. Predicted cross-reactivity based on sequence identity: Pig (100%) and Chicken (100%).

Alternate Names for SET Antibody

  • 2PP2A
  • HLA-DR-associated protein II
  • I2PP2A
  • I-2PP2A
  • Inhibitor of granzyme A-activated DNase
  • inhibitor-2 of protein phosphatase-2A
  • IPP2A2
  • Phosphatase 2A inhibitor I2PP2A
  • protein phosphatase type 2A inhibitor
  • protein SET
  • SET nuclear oncogene
  • SET translocation (myeloid leukemia-associated)
  • Template-activating factor I
  • Template-Activating Factor-I, chromatin remodelling factor


SET belongs to a family of multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. There are two named isoforms produced by alternative splicing : Isoform 1 and Isoform 2. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Isoform 1 and isoform 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. A chromosomal aberration involving SET is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with NUP214/CAN.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies


Isotype Controls

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Contact Information

Product PDFs


Gene Symbol SET

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