Recombinant Human Serum Amyloid A1 Protein

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SDS-Page: Recombinant Human Serum Amyloid A1 Protein [NBP2-34875] - man Serum Amyloid A1 Protein [NBP2-34875] - Human Serum Amyloid A1 Protein

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Func, PAGE, Bioactivity
Format
Carrier-Free
Concentration
LYOPH

Order Details

Recombinant Human Serum Amyloid A1 Protein Summary

Description
A biologically active protein to SAA1 (Species 9).

Source: E. coli

Amino Acid Sequence: RSFFSFLGEA FDGARDMWRA YSDMREANYI GSDKYFHARG NYDAAKRGPG GVWAAEAISD ARENIQRFFG HGAEDSLADQ AANEWGRSGK DPNHFRPAGL PEKY
Preparation
Method
Novus' biologically active proteins are stringently purified to provide only the safest and most highly effective proteins available. This protein was expressed in E. coli, purified by HPLC, QC tested by SDS-PAGE and Western Blot and validated on appropriate cell lines for bioactivity. All HPLC and bioactivity data is provided for your assurance.
Details of Functionality
Fully biologically active when compared to standard. The biological activity determined by a chemoattract bioassay using human monocytes is in a concentration range of 10-100 ng/ml.
Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
SAA1
Purity
> 98 % pure by SDS-PAGE and HPLC
Endotoxin Note
Less than 1 EU/ug of endotoxin as determined by LAL method

Applications/Dilutions

Theoretical MW
11.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Lyophilized from a 0.2 um filtered concentrated solution in 20 mM Tris-HCl, pH 9.0, 150 mM NaCl.
Preservative
No Preservative
Concentration
LYOPH
Purity
> 98 % pure by SDS-PAGE and HPLC
Reconstitution Instructions
Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL. Apportion stock solutions into working aliquots and store at <-20C.

Notes

This lyophilized preparation is stable at 2-8 degrees C, but should be kept at -20 degrees C for long term storage, preferably desiccated. Upon reconstitution, the preparation is most stable at -20 to -80 degrees C, and can be stored for one week at 2-8 degrees C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degrees C to -80 degrees C. Avoid repeated freeze/thaw cycles.

Alternate Names for Recombinant Human Serum Amyloid A1 Protein

  • MGC111216
  • PIG4
  • SAA
  • SAA1
  • SAA2
  • serum amyloid A protein
  • Serum Amyloid A1
  • TP53I4
  • tumor protein p53 inducible protein 4

Background

Serum Amyloid A protein-1 (SAA1) is a multifunctional apolipoprotein that circulates as part of the HDL complex. It can displace ApoA1 as the major apolipoprotein in HDL complexes and reduce the capacity of HDL for reverse cholesterol transport. In response to proinflammatory cytokines, SAA1 is prominently produced in liver and also in human but not mouse adipose tissue. Circulating SAA1 levels can increase by as much as 1000-fold during inflammation. SAA1 induces monocyte and macrophage chemotaxis and activation through binding to CD36/SR-B3, SR-B1, FPRL1, TLR2, and RAGE. It can also opsonize and promote the clearance of Gram negative bacteria.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol SAA1
Uniprot