Serotonin N-acetyltransferase Antibody


Western Blot: Serotonin N-acetyltransferase Antibody [NB100-135] - Samples of 1E7 homogenates and bacterially expressed hAANAT were loaded, which contained similar levels of AANAT activity in 65 ug and 2.6 ng of protein.
Immunocytochemistry/ Immunofluorescence: Serotonin N-acetyltransferase Antibody [NB100-135] - AANAT in COS7 and 1E7 cells detected by ICC. Cells were grown on two-well chamber slides and fixed with 2.5% glutaraldehyde; more

Product Details

Reactivity Hu, Pm, Bv(-), Ch(-), Rt(-), Ze(-)Species Glossary
Applications WB, ICC/IF
Please see the vial label for concentration. If unlisted please contact technical services.

Serotonin N-acetyltransferase Antibody Summary

Human Serotonin N-acetyltransferase [UniProt# Q16613]
This is specific for primate AANAT (3,4).
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Eluted in 0.1N glacial acetic acid containing 0.1% BSA & neutralized using 10x PBS
0.05% Thimerosal
Please see the vial label for concentration. If unlisted please contact technical services.
Immunogen affinity purified


Application Notes
This Serotonin N-acetyltransferase antibody is useful for Immunocytochemistry/Immunofluorescence and Western Blot. By Western blot, this antibody recognizes a band at 23 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
23 kDa
Read Publications using NB100-135.

Reactivity Notes

Human and rhesus macaque. The antibody does not recognize rat, bovine, chicken or zebrafish.

Alternate Names for Serotonin N-acetyltransferase Antibody

  • AA-NAT
  • aralkylamine N-acetyltransferaseEC
  • arylalkylamine N-acetyltransferase
  • Serotonin acetylase
  • SNATserotonin N-acetyltransferase


Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme is melatonin synthesis. Hormonal melatonin has been implicated in sleep and circadian clock function, and acts as"the hormone of the night." Large changes in the abundance of AANAT are believed to be responsible for the large day/night rhythms in melatonin synthesis in the pineal gland and retina (1,2). Most research shows that AANAT activity is regulated by controlling the steady-state levels of the protein. Recent research, however, suggests that another mechanism may also play a role in controlling melatonin production without altering AANAT protein and activity. This mechanism may explain the sudden physiological increase in circulating melatonin observed at the onset of the dark period in humans (3).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Serotonin N-acetyltransferase Antibody (NB100-135)(5)

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Serotonin N-acetyltransferase Antibody (NB100-135). (Showing 1 - 1 of 1 FAQs).

  1. We would like to know if this antibody can be used for bovine samples?
    • Our Serotonin N-acetyltransferase antibody NB100-135 cannot be used in bovine samples. We have evidence that it will not detect the bovine protein.

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Contact Information

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Gene Symbol AANAT

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