SCP3/SYCP3 Antibody


Western Blot: SCP3 Antibody [NB300-232] - Analysis of SCP3 in mouse testis protein.
Immunocytochemistry/ Immunofluorescence: SCP3/SYCP3 Antibody [NB300-232] - SCP3 Antibody [NB300-232] - SCP3 labeled in mouse pachytene preparation (red), using NB300-232 SCP3 antibody. CDK2 staining, near teleomeres, is more
Immunohistochemistry-Paraffin: SCP3/SYCP3 Antibody [NB300-232] - IHC-P analysis of formalin fixed paraffin embedded tissue section of mouse testes using SCP3 antibody at 1:200 dilution. Specific staining may be seen in more
Immunohistochemistry-Paraffin: SCP3 Antibody [NB300-232] - Analysis of SCP3 in human testis using DAB with hematoxylin counterstain.

Product Details

Reactivity Hu, Mu, Rt, Po, Bv, Ch, Fe, PaSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr, IHC-P
1 mg/ml

SCP3/SYCP3 Antibody Summary

A synthetic peptide made to the C-terminal region of the human SCP3 protein. [UniProt# Q8IZU3]
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
0.09% Sodium Azide
1 mg/ml
Immunogen affinity purified


Application Notes
This SCP3 antibody is useful for Immunofluorescence, Immunohistochemistry (Frozen and Paraffin), Immunocytochemistry and Western blot where a band is seen at ~28 kDa.
Control Peptide
SCP3/SYCP3 Peptide (NB300-232PEP)
Reviewed Applications
Read 1 Review rated 4
NB300-232 in the following application:

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NB300-232 in the following applications:

Reactivity Notes

Human, rat, pig, bovine and mouse. Chicken reactivity reported in scientific literature (PMID: 26096940). Parasite, and Feline reactivity reported in scientific literature (PMID: 27084479).

Alternate Names for SCP3/SYCP3 Antibody

  • anti-SCP3
  • COR1
  • MGC71888
  • SCP3 chromosome 3 open reading frame 8
  • SCP3 COR1
  • SCP3
  • SCP-3
  • SYCP3
  • synaptonemal complex protein 3


SCP3 (Synaptonemal complex protein 3) is a DNA-binding nuclear protein that belongs to XLR/SYCP3 family and is an essential structural component of the transverse filaments of synaptonemal complexes formed between homologous chromosomes during meiotic prophase. Synaptonemal complex develops during prophase of first meiosis, wherein it allows the synapse as well as recombination between maternal - paternal chromosome, and SCP3 is essential to hold cohesin complex between homologous chromosomes, which avoid premature segregation thereby preventing aneuploidies. SCP3 is involved in phosphorylation of HORMAD1 and HORMAD2. It is essential to development of testis (where it is primarily localized) and defective SCP3 may leads to spermatogenic failure type 4 (SPGF4). SCP3 deificient mouse depicts high numbers of aneuploidies in oocytes and offspring. SCP3 is also expressed in certain malignancies including human acute lymphatic leukemias, cervical cancer cells, lung cancer cells etc.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu
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Applications: WB, Flow
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Species: Hu
Applications: WB, IHC
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Applications: WB, IP
Species: Hu
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Species: Hu
Applications: WB
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP, PLA
Species: Hu, Mu
Applications: WB, IHC, IHC-P, PEP-ELISA
Species: Hu, Rt, Ca, Mk
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB
Species: Hu, Mu, Ce, Ch
Applications: WB, ChIP, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Ce
Applications: ELISA, ICC/IF, IHC
Species: Hu
Applications: WB, IHC
Species: Hu, Mu
Applications: WB, ChIP, ELISA, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu, Rt, Ca
Applications: IP (-), WB, Simple Western, Flow, ICC/IF, IHC, IHC-P
Species: Hu
Applications: ICC/IF, IHC, IHC-P

Publications for SCP3/SYCP3 Antibody (NB300-232)(25)

We have publications tested in 6 confirmed species: Human, Mouse, Bovine, Chicken, Feline, Parasite.

We have publications tested in 5 applications: ICC/IF, IHC, IHC-Fr, IHC-P, WB.

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Showing Publications 1 - 10 of 25. Show All 25 Publications.
Publications using NB300-232 Applications Species
Hanna RE, Moffett D, Forster FI et al. Fasciola hepatica: a light and electron microscope study of the ovary and of the development of oocytes within eggs in the uterus provides an insight into reproductive strategy. Vet. Parasitol. 2016 May 15 [PMID:27084479] (ICC/IF, IHC-P, Parasite, Feline) ICC/IF, IHC-P Parasite, Feline
Heeren AM, He N, de Souza AF et al. On the development of extragonadal and gonadal human germ cells. Biol Open. 2016 Feb 1 [PMID:26834021]
Cadalbert LC, Ghaffar FN, Stevenson D et al. Mouse Tafazzin Is Required for Male Germ Cell Meiosis and Spermatogenesis PLoS ONE 2015 Jun 27 [PMID:26114544] (ICC/IF, WB, Mouse) ICC/IF, WB Mouse
de Melo Bernardo A, Heeren AM, van Iperen L et al. Meiotic wave adds extra asymmetry to the development of female chicken gonads Mol. Reprod. Dev. 2015 Jun 20 [PMID:26096940] (IHC-Fr, Chicken) IHC-Fr Chicken
Shen W, Liang G, Zhang X et al. Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse Stem Cells Dev. 2015 Jun 17 [PMID:26083127]
Gruhn JR, Rubio C, Broman KW et al. Cytological Studies of Human Meiosis: Sex-Specific Differences in Recombination Originate at, or Prior to, Establishment of Double-Strand Breaks. PLoS One 2013 Dec 20 [PMID:24376867] (IHC, ICC/IF, Human) IHC, ICC/IF Human
Rowsey R, Kashevarova A, Murdoch B et al. Germline mosaicism does not explain the maternal age effect on trisomy. Am J Med Genet A. 2013 Aug 15 [PMID:23950106] (IHC, ICC/IF, Human) IHC, ICC/IF Human
Yuan J, Zhang D, Wang L et al. No evidence for neo-oogenesis may link to ovarian senescence in adult monkey. Stem Cells 2013 Jul 29 [PMID:23897655]
Lu LY, Xiong Y, Kuang H et al. Regulation of the DNA damage response on male meiotic sex chromosomes. Nat Commun 2013 Jun 28 [PMID:23812044] (ICC/IF, Human) ICC/IF Human
Link J, Jahn D, Schmitt J et al. The Meiotic Nuclear Lamina Regulates Chromosome Dynamics and Promotes Efficient Homologous Recombination in the Mouse. PLoS Genet 2013 Jan [PMID:23382700] (ICC/IF, Mouse) ICC/IF Mouse
Show All 25 Publications.

Reviews for SCP3/SYCP3 Antibody (NB300-232) (1) 41

Average Rating: 4
(Based on 1 reviews)
We have 1 review tested in 1 application: IHC-P.

Reviews using NB300-232:
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Images Ratings Applications Species Date Details
Immunohistochemistry-Paraffin SCP3/SYCP3 NB300-232
reviewed by:
IHC-P 07/12/2012


Special ApplicationsThe antibody works in adult marmoset testis but not in neonate nor juvenile testis as spermatogensis has not taken place. However, we only observe the expression in the spermatozoa, which causes a bit concern. This is because that SCP3 was reported to be expressed in the spermatocyte, which was not observed in adult marmoset testis.

Product General Protocols

View specific protocols for SCP3/SYCP3 Antibody (NB300-232): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for SCP3/SYCP3 Antibody (NB300-232). (Showing 1 - 5 of 5 FAQs).

  1. What was the dilution used for the CDK2 antibody in the ICC staining?
    • The antibody was used at a dilution of 1:500 for this image. 
  2. Is it a monoclonal antibody or polyclonal antibody?
    • This antibody is a rabbit polyclonal antibody. 
  3. What was the incubation time and temperature for this CDK2 antibody?
    • Primary incubation was performed at 4C overnight
  4. Was a permeabilization step performed for the mouse pachytene cells?
    • Our lab did perform a permeabilization step for this staining. The lab used 0.15% Triton-X in the fixation buffer. The tissues were then incubated for 2 hours.
  5. Could you tell us immunogen sequence of this antibody?
    •  The exact immunogen sequence for our product NB300-232 is proprietary. We can tell you that the immunogen falls between aa185-236 of the human SYCP3 protein (Uniprot Site).

Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB300-232AF405
Alexa Fluor (R) 488 Labeled NB300-232AF488
Alexa Fluor (R) 647 Labeled NB300-232AF647
Alexa Fluor (R) 700 Labeled NB300-232AF700
Biotin Labeled NB300-232B
DyLight 405 Labeled NB300-232V
DyLight 488 Labeled NB300-232G
DyLight 550 Labeled NB300-232R
DyLight 650 Labeled NB300-232C
FITC Labeled NB300-232F
HRP Labeled NB300-232H

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Blogs on SCP3/SYCP3.

SCP3: A Key to Meiotic Recombination, Sterility and Cancer
Synaptonemal Complex Protein 3 (SCP3), which is a protein present in the synaptonemal complex which is responsible for pairing, synapsis, and recombination of homologous chromosomes during meiosis. Meiosis, in basic terms, is where germ cells divide t...  Read full blog post.

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Gene Symbol SYCP3

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