SCD-1 Antibody [FITC]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

SCD-1 Antibody [FITC] Summary

Immunogen
Synthetic peptide made to an internal portion of human SCD (within residues 50-100). [Swiss-Prot# O00767]
Localization
endoplasmic reticulum membrane.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SCD
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
Application Notes
This SCD antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band can be seen at ~41 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
41 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SCD-1 Antibody [FITC]

  • FADS5
  • MSTP008
  • SCD1
  • SCD-1
  • SCDOS
  • Stearoyl-CoA desaturase

Background

SCD (stearoyl-CoA desaturase, or SCD1) is the terminal component of liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a range of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (de novo synthesis of monounsaturated fats from saturated fatty acids). SCD1 promoter region is bound by a wide array of transcription factors, including SREBP-1 and PPAR-alpha and the expression of SREBP-1 as well as SCD1 is upregulated by PI3K/mTOR signaling. Moreover, SCD1 transcription is hormonally upregulated by insulin and growth factors, but inhibited by estrogen and leptin. Oleate (an 18:1 fatty acid) is the major monounsaturated fatty acid of membrane phospholipids, triglycerides, cholesteryl esters, wax esters and alkyl-1,2-diacylglycerol. The ratio of unsaturated to saturated fatty acids is one of the factors influencing membrane fluidity; its alteration is important in a number of diseases, such as cancer, diabetes, obesity, and neurological, vascular and heart disease. This ratio, referred to as Desaturation Index, can be analyzed for multiple fatty acids in plasma and represents a potential biomarker of SCD inhibition.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SCD
Entrez