SAP102 Antibody (S19-2)

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Western Blot: SAP102 Antibody (S19-2) [NBP1-21672] - Rat brain extract
Immunocytochemistry/ Immunofluorescence: SAP102 Antibody (S19-2) [NBP1-21672] - analysis using Mouse Anti-SAP102 Monoclonal Antibody, Clone S19-2. Tissue: Neuroblastoma cell line SK-N-BE. Species: Human. Fixation: 4% ...read more

Product Details

Summary
Reactivity RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P, IP
Clone
S19-2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

SAP102 Antibody (S19-2) Summary

Immunogen
Fusion protein amino acids 1-120 of rat SAP102.
Localization
Basolateral Cell Membrane, Cytoplasm, Cell Junction, Synapse, Postsynaptic Cell Membrane, Postsynaptic Density, Growth Cone
Specificity
Detects approx 105kDa. No cross-reactivity against PSD95, SAP97 or Chapsyn-110.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
DLG3
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 1:10-1:500
Application Notes
1 ug/ml was sufficient for detection of Sap102 in 10 ug of rat brain lysate by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.
Publications
Read Publication using NBP1-21672.

Reactivity Notes

Based on homology, It's predicted to detect Human and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4) and 50% Glycerol
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Protein G purified

Alternate Names for SAP102 Antibody (S19-2)

  • discs, large homolog 3 (Drosophila)
  • KIAA1232discs, large homolog 3 (neuroendocrine-dlg, Drosophila)
  • MRX90MRX
  • NEDLGdisks large homolog 3
  • neuroendocrine-DLG
  • SAP-102
  • SAP102NE-Dlg
  • Synapse-associated protein 102
  • XLMR

Background

Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal (1, 2). SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homolgy 3 domain and a guanylate kinase domain (3). All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-Daspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway (3, 4). SAP102 also interacts with synaptic ras- GTPase activating protein synGAP through its PDZ domains (3). In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SAP102 Antibody (NBP1-21672)(1)

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol DLG3
Entrez
Uniprot