SAP102 Products

Description

Synapse-Associated Protein 102 (SAP102) is one of a family of plasma membrane-associated proteins found in synaptic junctions. Like other members of the family, SAP102 has three ~90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP102 is believed to participate in the clustering of certain proteins, including NMDA receptors, shaker-type potassium channels at the synaptic membrane in CNS neurons. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP102 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP102 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

Bioinformatics

Entrez	1741 Human 53310 Mouse 58948 Rat
Uniprot	AAH93864 Human NM_021120 Human NP_066943 Human NP_066943.2 Human Q5JUW6 Human Q62936 Rat Q92796 Human
Product By Gene ID	1741
Alternate Names	discs, large homolog 3 (Drosophila) KIAA1232discs, large homolog 3 (neuroendocrine-dlg, Drosophila) MRX90MRX NEDLGdisks large homolog 3 Neuroendocrine-DLG neuroendocrine-DLG SAP-102 SAP102NE-Dlg Synapse-associated protein 102 XLMR

Research Areas for SAP102

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Neuroscience