S1P5/EDG-8 Antibody (1196A) [Phycoerythrin]

Images

 
HEK293 human embryonic kidney cell line transfected with mouse S1P5/EDG-8 and eGFP were stained with either (A) Rabbit Anti-Mouse S1P5/EDG‑8 PE‑conjugated Monoclonal Antibody (Catalog # FAB9084P) or (B) Normal ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
1196A
Clonality
Monoclonal
Host
Rabbit
Conjugate
Phycoerythrin

S1P5/EDG-8 Antibody (1196A) [Phycoerythrin] Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
Mouse S1P5/EDG-8 peptide corresponding to the N-terminal extracellular sequence
Accession # Q91X56
Specificity
Detects mouse S1P5/EDG-8 in Western blots.
Source
N/A
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
S1pr5
Purity Statement
Protein A or G purified from cell culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for S1P5/EDG-8 Antibody (1196A) [Phycoerythrin]

  • EDG8
  • Edg-8
  • EDG8S1P receptor Edg-8
  • Endothelial differentiation G-protein-coupled receptor 8
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
  • LPB4
  • S1P receptor 5
  • S1P5
  • S1PR5
  • sphingosine 1-phosphate receptor 5
  • sphingosine 1-phosphate receptor EDG8
  • Sphingosine 1-phosphate receptor Edg-8
  • sphingosine-1-phosphate receptor 5
  • SPPR-1
  • SPPR-2

Background

S1P5 (Sphingosine-1 Phosphate receptor 5), also known as EDG-8 (Endothelial Differentiation Gene 8), is a 43-45 kDa member of the EDG family, S1P-binding subfamily of GPCRs. Along with S1P1 -S1P4 (or EDG-1, EDG-5, EDG-3 and EDG-6, respectively), S1P5 is known to bind S1P, a lipid synthesized by platelets, neutrophils, smooth muscle cells, mast cells and select fibroblasts. Mouse S1P5 is a 400 amino acid (aa) 7-transmembrane glycoprotein that is expressed on brain endothelium, renal mesangial cells, Ly6C+ (in human CD14+CD16-) monocytes, pre- and mature oligodendrocytes, and CD27-CD116+ (mature) NK cells. S1P5 appears to play a role in cell trafficking. On monocytes and NK cells, S1P5 promotes cell migration out of the bone marrow, a phenomenon that may not be related to an S1P concentration gradient. S1P5 also helps maintain the integrity of the blood-brain-barrier. On oligodendrocytes and precursors, S1P5 appears to regulate cell survival and pseudopod extension. The extracellular segment of mouse S1P5 shares 96% and 94% aa sequence identity with rat and human S1P5 extracellular domains, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

MAB7089
Species: Mu
Applications: Flow, IHC, CyTOF-ready
NBP3-05160
Species: Hu
Applications: ICC/IF, IHC, IHC-P
NBP2-26691
Species: Hu, Mu, Rt, Pm
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-24762
Species: Hu, Mu
Applications: WB, IHC, IHC-P
NBP2-24500
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
NBP1-03363
Species: Hu, Mu, Rt, Ch
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P
NBP2-37477
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
NBP1-84903
Species: Hu, Mu
Applications: WB, ICC/IF, IHC-P
NBP2-25160
Species: Hu, Mu, Rt, Po, Bv, Ca, Eq
Applications: WB, ICC/IF, IHC
NBP1-58359
Species: Hu
Applications: WB, IHC, IHC-P
AF6396
Species: Hu
Applications: WB
NLS1895
Species: Hu, Mu, Rt, Bt, Ha, Pm, Pm
Applications: Flow, IHC, IHC-P
NBP1-43299
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
NBP1-71867
Species: Hu, Mu
Applications: WB, IHC, IHC-P, IP
NLS426
Species: Hu, Mu
Applications: ICC/IF, IHC, IHC-P
MAB1230
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, ICC, KO
AF887
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, CyTOF-ready, ICFlow

Publications for S1P5/EDG-8 Antibody (FAB9084P) (0)

There are no publications for S1P5/EDG-8 Antibody (FAB9084P).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for S1P5/EDG-8 Antibody (FAB9084P) (0)

There are no reviews for S1P5/EDG-8 Antibody (FAB9084P). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for S1P5/EDG-8 Antibody (FAB9084P) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB9084U
Alexa Fluor 405 FAB9084V
Alexa Fluor 488 FAB9084G
Alexa Fluor 594 FAB9084T
Alexa Fluor 647 FAB9084R
Alexa Fluor 700 FAB9084N
Alexa Fluor 750 FAB9084S
Phycoerythrin FAB9084P

Additional S1P5/EDG-8 Products

Bioinformatics Tool for S1P5/EDG-8 Antibody (FAB9084P)

Discover related pathways, diseases and genes to S1P5/EDG-8 Antibody (FAB9084P). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for S1P5/EDG-8 Antibody (FAB9084P)

Discover more about diseases related to S1P5/EDG-8 Antibody (FAB9084P).
 

Pathways for S1P5/EDG-8 Antibody (FAB9084P)

View related products by pathway.

PTMs for S1P5/EDG-8 Antibody (FAB9084P)

Learn more about PTMs related to S1P5/EDG-8 Antibody (FAB9084P).

Blogs on S1P5/EDG-8

There are no specific blogs for S1P5/EDG-8, but you can read our latest blog posts.
Coronavirus Brochure

Customers Who Bought This Also Bought

Contact Information

Learn the difference between western blot and simple western

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our S1P5/EDG-8 Antibody (1196A) [Phycoerythrin] and receive a gift card or discount.

Bioinformatics

Gene Symbol S1pr5
Uniprot