S1P4/EDG-6 Antibody (1) - C-terminus - BSA Free

Immunocytochemistry/Immunofluorescence: S1P4/EDG-6 Antibody (1) [NBP2-66579]

• Reactivity: Hu
• Applications: WB, Flow, ICC/IF
• Clone: 1
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free

S1P4/EDG-6 Antibody (1) - C-terminus - BSA Free Summary

• Description: Novus Biologicals Mouse S1P4/EDG-6 Antibody (1) - C-terminus - BSA Free (NBP2-66579) is a monoclonal antibody validated for use in WB, Flow and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with Unique synthetic peptide derived from the C-terminal of the EDG6 (S1P4) protein and mouse myeloma cells.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: S1PR4
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot 5 - 10 ug/mL
• Application Notes: Optimal concentration should be evaluated by serial dilutions..

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.08% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for S1P4/EDG-6 Antibody (1) - C-terminus - BSA Free

• EDG6
• EDG6S1P receptor Edg-6
• Endothelial differentiation G-protein coupled receptor 6
• endothelial differentiation, G-protein-coupled receptor 6
• endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor6,endothelial differentiation, G protein coupled receptor 6
• S1P receptor 4
• S1P4
• S1P4LPC1
• S1PR4
• SLP4
• sphingosine 1-phosphate receptor 4
• Sphingosine 1-phosphate receptor Edg-6
• sphingosine-1-phosphate receptor 4

Background

S1P4/EDG-6 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for S1P4/EDG-6 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. S1P4/EDG-6 is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the S1P4/EDG-6 receptor is the sphingosine 1-phosphate receptor-4 (S1P4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: S1PR4
• Uniprot:
  • O95977()