Recombinant Human RXR alpha/NR2B1 Protein

SDS-Page: Recombinant Human RXR alpha/NR2B1 Protein [NBC1-18416] - 3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

• Reactivity: Hu
• Applications: PAGE
• Concentration: 1 mg/ml

Recombinant Human RXR alpha/NR2B1 Protein Summary

• Description: An un-tagged recombinant protein corresponding to the amino acids111-228 of Human RXR alpha/NR2B1
  
  

  Source: E.coli

  Amino Acid Sequence: MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE

• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: RXRA
• Purity: >95%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • SDS-Page
• Theoretical MW: 13.5 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20 mM Tris-HCl buffer (pH 7.5) 0.1 M NaCl, 5mM beta-Mercaptoethanol
• Preservative: No Preservative
• Concentration: 1 mg/ml
• Purity: >95%, by SDS-PAGE

Alternate Names for Recombinant Human RXR alpha/NR2B1 Protein

• FLJ00280
• FLJ00318
• FLJ16020
• MGC102720
• NR2B1
• NR2B1FLJ16733
• Nuclear receptor subfamily 2 group B member 1
• retinoic acid receptor RXR-alpha
• Retinoid X receptor alpha
• retinoid X receptor, alpha
• RXR alpha
• RXRA

Background

The retinoid X receptor(RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors(RAR), thyroid hormone receptors(TR), vitamin D receptors and peroxisome proliferators-activated receptors(PPAR). The RXR family includes three difference isoforms ; RXR alpha, beta, gamma. Human RXR alpha gene is localized on 9q34.9 and encodes two major isoforms(RXR alpha1, RXR alpha2). The DNA binding domain of RXR(111-228aa) was over expressed in E.coli and purified by using conventional column chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: RXRA