RNase L Antibody (2E9) [Alexa Fluor™ Plus 680]

• Reactivity: Hu, Ha, Pm, Mu(-), Rt(-)
• Applications: WB, ELISA, IHC, KO
• Clone: 2E9
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 680

RNase L Antibody (2E9) [Alexa Fluor™ Plus 680] Summary

• Immunogen: Purified full-length recombinant human RNaseL produced in insect cells. [UniProt# Q05823]
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: RNASEL
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockout Validated
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

This antibody does not react with mouse or rat.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for RNase L Antibody (2E9) [Alexa Fluor™ Plus 680]

• 2-5A-dependent ribonuclease
• 2-5A-dependent RNase
• 2'-5'-oligoisoadenylate synthetase-dependent
• EC 3.1.26.-
• HPC1
• interferon-induced 2-5A-dependent RNase
• MGC104972
• MGC133329
• PRCA1
• prostate cancer 1
• Ribonuclease 4
• ribonuclease L (2'-5'-oligoisoadenylate synthetase-dependent)
• Ribonuclease L
• RNase L
• RNS4DKFZp781D08126

Background

RNase L is a virally induced endoribonuclease that is also the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation through total RNA degradation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L is thought to function in counteracting prostate cancer, via apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RNASEL