RIPK2 Antibody (1018218) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 1018218
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

RIPK2 Antibody (1018218) [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived human RIPK2/RIP2
  Met1-Met540
  Accession # O43353
• Specificity: Detects human RIPK2/RIP2 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for RIPK2 Antibody (1018218) [Alexa Fluor® 594]

• CARD3
• CARD-containing IL-1 beta ICE-kinase
• CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase
• CARD-containing interleukin-1 beta-converting enzyme-associated kinase
• CARDIAKCCK
• EC 2.7.11
• EC 2.7.11.1
• GIG30
• growth-inhibiting gene 30
• receptor interacting protein 2
• receptor-interacting protein (RIP)-like interacting caspase-like apoptosisregulatory protein (CLARP) kinase
• Receptor-interacting protein 2
• receptor-interacting serine/threonine-protein kinase 2
• receptor-interacting serine-threonine kinase 2
• RICK
• RICKGIG30
• RIP2
• RIP-2
• RIP2CARD-carrying kinase
• RIPK2
• RIP-like-interacting CLARP kinase

Background

Receptor-interacting serine/threonine-protein kinase 2, also known as RIPK2 or RIP-2, is a  540 amino acids (aa) Serine/threonine/tyrosine kinase encoded by the RIPK2 gene. RIP-2, a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, plays an essential role in modulation of innate and adaptive immune responses. Human RIP2 is an adapter protein necessary for signal propagation of the Nucleotide-binding-oligomerization-domain-containing proteins 1/2 (NOD1 and NOD2). Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize, and recruit RIPK2 through the C-terminal caspase recruitment domain (CARD). Human and mouse RIPK2 aa sequences are 84% identical .

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.