RGM-C/Hemojuvelin Antibody [DyLight 650]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: DyLight 650

RGM-C/Hemojuvelin Antibody [DyLight 650] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse RGM-C isoform 1 (R&D Systems, Catalog # 3634-RG)
  Gln33-Asp393 (Ile379Val)
  Accession # Q7TQ32
• Specificity: Detects mouse RGM-C in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human RGM‑C is observed and less than 5% cross-reactivity with recombinant mouse (rm) RGM-A and rmRGM-B is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: HFE2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for RGM-C/Hemojuvelin Antibody [DyLight 650]

• DL-M
• haemojuvelin
• hemochromatosis type 2 (juvenile)
• Hemojuvelin
• HFE2
• HFE2AMGC23953
• HJV
• HJVHemochromatosis type 2 protein
• JH
• repulsive guidance molecule c
• RGMC
• RGM-C
• RGMCRGM domain family member C

Background

The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HFE2